A Historic Photo: Torvalds and Gates Together
When #Linux met #Microsoft: a historic photo of Linus Torvalds and Bill Gates standing side by side for the very first time.
https://linuxiac.com/a-historic-photo-torvalds-and-gates-together/
From the hell is freezing department. #azure would be not existing without Linux.
And this fuels also the joke that the relationship between #WNT and #VMS is the same as between #IBM and #HAL.
Abstract The Wnt pathway plays a key role in cell growth, survival, and self-renewal which is frequently hyperactive in various cancers. It is categorized into canonical and non-canonical Wnt pathways depending upon the influence of the β-catenin protein. Gene expressions are often altered by small non-coding RNAs, known as microRNAs (miRNAs) leading to regulation involving cell-proliferating pathways like Wnt in various cancers, including breast. miRNAs frequently act as an oncogene or a tumor-suppressor depending upon their regulatory roles. In this review article, the significance of the Wnt pathway in cancer progression, most importantly breast cancer is widely explained. The role of miRNAs in modulating varied pathways especially the Wnt pathway in breast cancer is also reviewed here. Breast cancer suppression using new-age miRNA therapeutics is showing promising results and the use of different nanocarriers for therapeutic delivery is increasing its efficacy. Targeting the Wnt pathway and its related genes can show a new path for the treatment of cancer stem cells (CSCs) of breast and other cancers as the Wnt pathway plays a pivotal role in maintaining the stemness of CSCs. Moreover, controlling the Wnt pathway through miRNA nanocarrier can give another dimension to breast cancer therapy by inhibiting aggressive and tricky breast cancer stem cells.
Ruim dertig procent van alle schoolbestuurders in het basis- en middelbaar onderwijs zat in 2023 tegen het salarisplafond van de Wet normering topinkomens. Een klein deel van de bestuurders verdiende zelfs meer dan die zogeheten ‘Balkenendenorm’.
White Noise Trio
https://mobilize.berlin/events/e39b6ed3-3699-427a-a834-d289bace112c
Nov 15, 2024, 12:30:00 PM - GMT+1 - Peppi Guggenheim, 12043, Berlin, Deutschland - Robin Hartkopf (Drums) Stefan Merz (Piano) Florian Dupuy (Double Bass) The White Noise Trio pushes the boundaries of the classic jazz trio and inspires with atmospheric, almost cinematic compositions.…
The Wnt/β-catenin signaling pathway plays numerous essential roles in animal development and tissue/stem cell maintenance. The activation of genes regulated by Wnt/β-catenin signaling requires the nuclear accumulation of β-catenin, a transcriptional co-activator. β-catenin is recruited to many Wnt-regulated enhancers through direct binding to T-cell factor/lymphoid enhancer factor (TCF/LEF) family transcription factors. β-catenin has previously been reported to form phase-separated biomolecular condensates (BMCs), which was implicated as a component of β-catenin’s mechanism of action. This function required aromatic amino acid residues in the intrinsically disordered regions (IDRs) at the N- and C-termini of the protein. In this report, we further explore a role for β-catenin BMCs in Wnt target gene regulation. We find that β-catenin BMCs are miscible with LEF1 BMCs in vitro and in cultured cells. We characterized a panel of β-catenin mutants with different combinations of aromatic residue mutations in human cell culture and Drosophila melanogaster. Our data support a model in which aromatic residues across both IDRs contribute to BMC formation and signaling activity. Although different Wnt targets have different sensitivities to loss of β-catenin’s aromatic residues, the activation of every target examined was compromised by aromatic substitution. These mutants are not defective in nuclear import or co-immunoprecipitation with several β-catenin binding partners. In addition, residues in the N-terminal IDR with no previously known role in signaling are clearly required for the activation of various Wnt readouts. Consistent with this, deletion of the N-terminal IDR results in a loss of signaling activity, which can be rescued by the addition of heterologous IDRs enriched in aromatic residues. Overall, our work supports a model in which the ability of β-catenin to form biomolecular condensates in the nucleus is tightly linked to its function as a transcriptional co-regulator.
Het IMF geeft steuntje in de rug aan het niet laten gelden van de Wet Normering Topinkomens voor DNB en AFM
#WNT
Al eerder schreef ik over het merkwaardige fenomeen dat de Wet Normering Topinkomens (WNT) niet geldt voor De Nederlandsche Bank (DNB) en de Autoriteit Financiële Markten (AFM) [1]. De Nederlandse …
Reviewing the Republic of Ireland's recent qualifiers against France and England, and discussing the new manager of the Men's National Team
Thomas Fricke (he/his)
Cytology and Genetics
Alexandra Beekers 🏳️🌈🌍
Peppi Guggenheim Live Music
Rhyothemis
PLOS Biology
Ellen Timmer
Irish Abroad
Derek Rae 🤖
Cell Chemical Biology