PLOS BiologyDec 12, 2024
Screen for novel kinase regulators by @Montse_Llanses @ERainero_lab &co shows that the α2β1 integrin/p38 signaling axis is needed for internalization of #integrin-bound #ECM, modulating cell migration & invasion in diverse #cancer cells #PLOSBiology https://plos.io/4gzKTbp
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

This study identifies novel kinase regulators of extracellular matrix (ECM) internalization through a high-content screen, characterizing the α2β1 integrin/p38 signaling axis as required for the internalization integrin-bound ECM, which modulates cell migration and invasion in breast, ovarian and pancreatic cancer cells.

PLOS BiologySep 16, 2024
How do integrins and paxillin interact at #FocalAdhesions? This study presents a 3D structure of the LIM3 domain of #paxillin, revealing a direct association between paxillin and the cytoplasmic tail of the #integrin beta subunit #PLOSBiology https://plos.io/3TrtFUw
A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits

How do integrins and paxillin interact at focal adhesions? Here, the authors present a 3D-structure of the LIM3 domain of paxillin which reveals a direct association between paxillin and the cytoplasmic tail of the integrin beta subunit.

PLOS BiologySep 16, 2024
How is cell basal geometry is regulated during epithelial #morphogenesis? @PichaudLab &co show that a pathway involving #laminin & #integrin adhesion coordinates remodelling of #EpithelialCell shape by patterning their basement membrane #PLOSBiology https://plos.io/4e457co
A dystroglycan–laminin–integrin axis coordinates cell shape remodeling in the developing Drosophila retina

Cell shape remodeling is a main driver of epithelial tissue morphogenesis, but how cell basal geometry is regulated remains unclear. This work identifies a novel morphogenetic pathway involving laminin and integrin adhesion that coordinates the remodelling of epithelial cell shape by patterning their basement membrane.

CellBioNewsMar 13, 2024

Study shows for the first time that different forms of #cellular #adhesion structures can interconvert.

#integrin

https://phys.org/news/2024-03-cellular-adhesion-interconvert.html

Study shows for the first time that different forms of cellular adhesion structures can interconvert

Cells form adhesion structures to anchor themselves in their environment. The coordinated assembly and disassembly of these adhesions also enables cells to move from one place to another.

Phys.org
The EMBO JournalSep 18, 2023

In our issue 18:
Reviews on ubiquitin-targeted bacterial effectors, and on satellite RNAs

Highlights on #ribonucleotide salvage for #mitochondrial #transcription, and plant defense against #m6A-RNA-containing viruses

Further articles on #intraflagellar transport, #replication initiation within #chromatin, #integrin-dependent cancer cell invasion…

https://www.embopress.org/toc/14602075/2023/42/18

The EMBO JournalAug 17, 2023
#Ovariancancer cells lacking tumor suppressor #PTEN require an ARF #GTPase module for #integrin-dependent #invasiveness
A #RefereedPreprint c/o @ReviewCommons by Konstantina Nikolatou, David Bryant et al
https://www.embopress.org/doi/full/10.15252/embj.2023113987
Show threadRichard SeverNov 23, 2022
@soragnilab @MingqingCai @biorxivpreprint the problem with author-selected keywords is they are not helpful unless selected from a controlled vocabulary (e.g. #integrin will not show up in a search for #celladhesion) and then you have to decide/agree on and maintain the taxonomy (which is a nightmare). it's feasible for things like Human Phenotype Ontology, but that's the exception rather than the rule. search normally solves things but here that just means we're back to the original issue
Hao YinNov 19, 2022

Airway #SmoothMuscleCell #Asthma Inflammation

SMMHC-driven #Integrin α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2022-00050

Pereda LabNov 7, 2022
#introduction
Hello, this is Jose M de Pereda and I run a research group at the Center for Cancer Research in #Salamanca (Spain) (#CSIC #USAL).
We study the structural and mechanistic basis of #integrin based #CellAdhesion complexes (mostly #Hemidesmosomes) and of #Rap1 signaling. Knowing in detail how these molecular systems work is essential to understand how they are altered in diseases.
We do multidisciplinary research: #StructuralBiology #Biochemistry, #Biophysics and a bit of #CellBiology
Tara MoriartySep 29, 2016
DDR1 and a4b1 #integrin regulate #collagen attachment. http://ht.ly/2KqA304tN9w #science #cellbiology