How is cell basal geometry is regulated during epithelial
#morphogenesis? @PichaudLab &co show that a pathway involving
#laminin &
#integrin adhesion coordinates remodelling of
#EpithelialCell shape by patterning their basement membrane
#PLOSBiology https://plos.io/4e457co
A dystroglycan–laminin–integrin axis coordinates cell shape remodeling in the developing Drosophila retina
Cell shape remodeling is a main driver of epithelial tissue morphogenesis, but how cell basal geometry is regulated remains unclear. This work identifies a novel morphogenetic pathway involving laminin and integrin adhesion that coordinates the remodelling of epithelial cell shape by patterning their basement membrane.
The protocol provides the step-by-step experimental methods for our @eLife paper "3D cell neighbour dynamics in growing pseudostratified epithelia" https://elifesciences.org/articles/68135.
See also our Tweetorial:
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RT @DagmarIber
How many neighbours does an epithelial cell have? And how stable are these interactions over time? #epithelialcell #topology #LSFM #SPIM
Check out our latest pre-print: https://www.biorxiv.org/content/10.…
https://twitter.com/DagmarIber/status/1368806675495452672
3D cell neighbour dynamics in growing pseudostratified epithelia
The 3D shape and dynamic organization of epithelial cells are far more complex than previously believed, but can be explained with simple physical principles based on lateral surface energy minimisation.
PLOS Biology
Dagmar Iber