A very small and short-term study found that aerobic exercise during a severe calorie deficit preserved muscle function, increasing mitochondrial protein synthesis in muscle tissue. Myofibrillar and sarcoplasmic protein synthesis was unchanged. Muscle collagen decreased, producing a more 'youthful' muscle composition.

Summary: https://www.sciencealert.com/working-out-while-losing-weight-keeps-muscles-young-study-finds

Original paper: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202502384RR

#Science #Exercise #CalorieRestriction #Fasting

Intermittent Fasting As Effective As Calorie Restriction

Share on PinterestExperts say there’s no compelling evidence of a “best” diet for weight loss. Anchiy/Getty ImagesIntermittent fasting resulted in similar weight loss as traditional calorie restriction, according to a ne…
#dining #cooking #diet #food #Nutrition #calorierestriction #intermittentfasting #nutrition #Traditionaldiets #weightloss
https://www.diningandcooking.com/2139543/intermittent-fasting-as-effective-as-calorie-restriction/

Long-Term Weight Loss: Is Extreme Calorie Restriction Sustainable?

Read more 👉 https://coach.org.uk/is-700-calories-enough/

#calories #diet #calorierestriction

Why eating less slows ageing: Lithocholic acid
https://www.nature.com/articles/d41586-024-04220-5
non-paywalled https://archive.fo/J3dHo
https://news.ycombinator.com/item?id=42478962

Lithocholic acid binds TULP3 to activate sirtuins/AMPK to slow ageing
https://www.nature.com/articles/s41586-024-08348-2

Lithocholic acid phenocopies anti-ageing effects of calorie restriction
https://www.nature.com/articles/s41586-024-08329-5

Lithocholic acid: https://en.wikipedia.org/wiki/Lithocholic_acid
* bile acid; solubilizes fats for absorption

#LithocholicAcid #ageing #aging #CalorieRestriction #sirtuins #AMPK #MolecularBiology

Medical supervision is crucial to monitor side effects, ensure nutritional needs are met, and manage any pre-existing health conditions in conjunction with the diet plan.

Read more 👉 https://coach.org.uk/is-700-calories-enough/

#calories #diet #calorierestriction #bodybuidling #strengthtraining #weightloss #nutrition

🏃‍♂️ Calorie-cutting mice still exercise, challenging exercise-energy belief

https://phys.org/news/2024-08-calorie-mice-energy-belief.html

#zoology #animals #mice #exercise #obesity #physiology #calorierestriction