Why eating less slows ageing: Lithocholic acid
https://www.nature.com/articles/d41586-024-04220-5
non-paywalled https://archive.fo/J3dHo
https://news.ycombinator.com/item?id=42478962

Lithocholic acid binds TULP3 to activate sirtuins/AMPK to slow ageing
https://www.nature.com/articles/s41586-024-08348-2

Lithocholic acid phenocopies anti-ageing effects of calorie restriction
https://www.nature.com/articles/s41586-024-08329-5

Lithocholic acid: https://en.wikipedia.org/wiki/Lithocholic_acid
* bile acid; solubilizes fats for absorption

#LithocholicAcid #ageing #aging #CalorieRestriction #sirtuins #AMPK #MolecularBiology

Why eating less slows ageing: this molecule is key

A naturally occurring compound involved in digestion lengthens lifespan in flies and makes old mice more youthful.