Mastodawn

As a doctor, here’s what I have learned from my own Alzheimer’s disease

I suddenly wore two hats — that of a retired physician who had cared for people with Alzheimer’s disease and now a person living with the same disorder.

I have a special interest in #Alzheimer’s disease. For nearly 25 years, I practiced general #neurology in Portland, Oregon, and some of my patients had #dementia. In 2012, while doing a genealogical DNA search, I inadvertently discovered that I have two copies of the #APOE-4 allele, meaning I had a very good chance of getting Alzheimer’s…

https://wapo.st/3ZWztZv

As a doctor, here’s what I have learned from my own Alzheimer’s disease

I suddenly wore two hats — that of a retired physician who had cared for people with Alzheimer’s disease and now a person living with the same disorder.

The Washington Post

Regenerative Research Fdn/NSCI Sep 5, 2024

👀 This week, Sally Temple attends the @National Institute on Aging (NIA) APOE workshop where she is presenting some exciting new data on "Investigating the impact of APOE4 on vascular cell phenotypes"

#alzheimers #APOE #dementia

Matt Willemsen Apr 1, 2024

The Hidden Cause of Alzheimer's May Have Been Identified a Century Ago
https://www.sciencealert.com/the-hidden-cause-of-alzheimers-may-have-been-identified-a-century-ago #medicine #MentalHealth #alzheimers #LipidDeposits #APOE #fat

The Hidden Cause of Alzheimer's May Have Been Identified a Century Ago

Alzheimer's disease is commonly associated with clumps and tangles of proteins building up in brain cells.

ScienceAlert

Matt Willemsen Feb 19, 2024

Herpes Virus May Double Your Risk of Dementia, Study Finds
https://www.sciencealert.com/herpes-virus-may-double-your-risk-of-dementia-study-finds #medicine #alzheimers #HerpesSimplex #HSV—1 #APOE #vaccine

Herpes Virus May Double Your Risk of Dementia, Study Finds

The virus behind the common cold sore could put people at greater risk of Alzheimer's disease.

ScienceAlert

Rhyothemis Jan 31, 2024

research article from 2005:

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

https://pubmed.ncbi.nlm.nih.gov/15650186

#HSV1 #hormones #herpesvirus #ApoE

Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender - PubMed

Herpes simplex virus type 1 (HSV-1) causes disease in humans and animals. Infection usually occurs via the neural route and possibly occurs via the hematogenous route. The latter, however, is the main route by which immunosuppressed individuals and neonates are infected. Gender-dependent differences …

PubMed

Javier Díaz-Nido Jun 4, 2023

APOE expression and secretion are modulated by mitochondrial dysfunction

This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction

https://elifesciences.org/articles/85779

Javier Díaz-Nido May 17, 2023

La actividad física ayuda a contrarrestar el riesgo genético del alzhéimer

#Neurociencia #Cerebro #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Neurodegeneración #Demencia #Alzheimer #Neurogenética #ApoE #EjercicioFísico #ActividadFísica #Deporte
#Biomedicina

https://www.agenciasinc.es/Noticias/La-actividad-fisica-ayuda-a-contrarrestar-el-riesgo-genetico-del-alzheimer

La actividad física ayuda a contrarrestar el riesgo genético del alzhéimer

Una investigación internacional liderada por la Universidad Complutense de Madrid integra en un único modelo la información que relaciona ejercicio y presencia de la proteína ApoE4, un marcador genético en el alzhéimer. Pese a que la capacidad protectora del deporte se reduce según avanza la enfermedad, no llega a eliminarse del todo y contribuye a retrasar el inicio de la sintomatología clínica.

Agencia SINC

Javier Díaz-Nido May 15, 2023

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

The male remained cognitively intact until 67 years of age despite carrying a PSEN1-E280A mutation. He had extremely elevated amyloid plaque burden and limited entorhinal Tau tangle burden.
He was heterozygous for a rare variant in RELN showing stronger ability to reduce human Tau phosphorylation in a knockin mouse.

#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #Tau #Reelin #ApoE #Dementia #Neurogenetics

https://www.nature.com/articles/s41591-023-02318-3

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man - Nature Medicine

Case report of an individual heterozygous for a rare RELN-COLBOS variant that confers resilience, via a gain-of-function mechanism, to Alzheimer’s disease.

Nature

scinexx - das wissensmagazin Apr 13, 2023

Steinzeit-Gen beeinflusst unsere Langlebigkeit. Günstige APOE-Genvarianten stammen von frühgeschichtlichen Einwanderern. #APOE #Genvariante #DNA #Steinzeit #Genetik #Lebensdauer https://www.scinexx.de/news/medizin/steinzeit-gen-beeinflusst-unsere-langlebigkeit/

Steinzeit-Gen beeinflusst unsere Langlebigkeit

Genetischer Import: Europäer verdanken ihre Langlebigkeit zum Teil jungsteinzeitlichen Einwanderern. Denn erst diese brachten eine günstige Genvariante

scinexx | Das Wissensmagazin

clawful Jan 30, 2023

Regular proton pump inhibitor use and incident dementia: population-based cohort study

The finding of this large population-based cohort study indicates that the use of proton pump inhibitors is associated with an increased risk of incident dementia, particularly among APOE ε4 heterozygotes.

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02478-y

#dementia #PPI #PPIs #APOE #acidreflux #GERD

Regular proton pump inhibitor use and incident dementia: population-based cohort study - BMC Medicine

Background To examine the association between regular use of proton pump inhibitors and the risk of incident dementia, including dementia subtypes, and whether the association differs between APOE genotypes. Methods Based on a prospective analysis of data from the UK Biobank, 501,002 individuals (female, 54.4%) aged between 40 and 70 years, who had no prevalent dementia at baseline, were enrolled between 2006 and 2010 and followed up to 2018. We compared all-cause dementia, Alzheimer’s disease (AD), and vascular dementia (VaD) incidence rates between proton pump inhibitor users and non-users by the Cox proportional hazard model. Results During 4,438,839 person-years of follow-up (median length of follow-up, 9.0 years), there were 2505 incident cases of all-cause dementia, including 932 cases of AD and 524 cases of VaD. The incident rate of all-cause dementia among proton pump inhibitor users was 1.06 events per 1000 person-years, compared with 0.51 events per 1000 person-years among non-users. After adjustment for multiple confounders and indications, the hazard ratios (HRs) of the proton pump inhibitor users were 1.20 (95% CI, 1.07–1.35) for incident all-cause dementia, 1.23 (95% CI, 1.02–1.49) for incident AD, and 1.32 (95% CI, 1.05–1.67) for incident VaD. In addition, the association between proton pump inhibitor use and all-cause dementia differed by APOE genotype (P for interaction = 0.048). Among APOE ε4 heterozygotes, the fully adjusted HR of proton pump inhibitor use was 1.46 (95% CI, 1.22–1.75) and 1.68 (95% CI, 1.36–2.07), especially for individuals aged 65 years and older. Conclusions The finding of this large population-based cohort study indicates that the use of proton pump inhibitors is associated with an increased risk of incident dementia, particularly among APOE ε4 heterozygotes.

BioMed Central