Older people with a genetic risk of Alzheimer's disease did not experience the expected increase in cognitive decline and dementia risk if they consumed relatively large amounts of meat. This is shown in a new study from Karolinska Institutet published in JAMA Network Open. The results may contribute to the development of more individually tailored dietary advice.
As a doctor, here’s what I have learned from my own Alzheimer’s disease
I suddenly wore two hats — that of a retired physician who had cared for people with Alzheimer’s disease and now a person living with the same disorder.
I have a special interest in #Alzheimer’s disease. For nearly 25 years, I practiced general #neurology in Portland, Oregon, and some of my patients had #dementia. In 2012, while doing a genealogical DNA search, I inadvertently discovered that I have two copies of the #APOE-4 allele, meaning I had a very good chance of getting Alzheimer’s…
👀 This week, Sally Temple attends the @National Institute on Aging (NIA) APOE workshop where she is presenting some exciting new data on "Investigating the impact of APOE4 on vascular cell phenotypes"
research article from 2005:
Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender
Herpes simplex virus type 1 (HSV-1) causes disease in humans and animals. Infection usually occurs via the neural route and possibly occurs via the hematogenous route. The latter, however, is the main route by which immunosuppressed individuals and neonates are infected. Gender-dependent differences …
APOE expression and secretion are modulated by mitochondrial dysfunction
This study presents compelling evidence that ApoE is upregulated in various models of mitochondrial respiratory chain dysfunction. The work is of fundamental interest for those studying neurodegeneration and the role of ApoE in Alzheimer's disease; future work will be needed to reveal the molecular basis of this dramatic phenotype.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #ApoE #Neurogenetics #Mitochondria #MitochondrialDysfunction
La actividad física ayuda a contrarrestar el riesgo genético del alzhéimer
#Neurociencia #Cerebro #Neurología #EnfermedadesNeurológicas #EnfermedadesNeurodegenerativas #Neurodegeneración #Demencia #Alzheimer #Neurogenética #ApoE #EjercicioFísico #ActividadFísica #Deporte
#Biomedicina
Una investigación internacional liderada por la Universidad Complutense de Madrid integra en un único modelo la información que relaciona ejercicio y presencia de la proteína ApoE4, un marcador genético en el alzhéimer. Pese a que la capacidad protectora del deporte se reduce según avanza la enfermedad, no llega a eliminarse del todo y contribuye a retrasar el inicio de la sintomatología clínica.
Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man
The male remained cognitively intact until 67 years of age despite carrying a PSEN1-E280A mutation. He had extremely elevated amyloid plaque burden and limited entorhinal Tau tangle burden.
He was heterozygous for a rare variant in RELN showing stronger ability to reduce human Tau phosphorylation in a knockin mouse.
#Biomedicine #Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #Tau #Reelin #ApoE #Dementia #Neurogenetics
Luis Falcon
🐦🔥nemo™🐦⬛ 🇺🇦🍉
MOVING TO Mastodon.Social
Regenerative Research Fdn/NSCI
Matt Willemsen
Rhyothemis
Javier Díaz-Nido