IGF-I plays an important role in oligodendrocyte survival and myelination. We used human recombinant IGF-I to
Peripheral nerve injury (PNI) heavily relies on the functional condition of Schwann cells (SCs) for effective repair. Evidence shows that SCs pyroptosis hinders neural regeneration. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive physical therapy. LIPUS significantly enhances motor function recovery, promotes axonal regeneration and remyelination, and decreases gast
Clinical trial: A Pilot Study: Dorsolateral Prefrontal Cortex Transcranial Magnetic Stimulation Target Engagement and Safety in Primary Progressive and Relapsing-remitting Multiple Sclerosis
Clinical trial: Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
Clinical trial: A Smart Phone Application to Improve Adoption of the 2024 KDIGO CKD Guidelines
There is a growing prevalence of age-related neurodegenerative diseases such as Alzheimer''s and Parkinson''s. Eight clinically approved CNS drugs were screened for activity against Ca.1, Orai1, and P2X7 channels and evaluated in neuroprotection assays. Several compounds demonstrated significant efficacy.
Raloxifene is a selective estrogen receptor modulator (SERM) with neuroprotective and neuropsychiatric effects. It has been approved for osteoporosis and breast cancer prevention. Its clinical translation faces challenges. Existing trials are limited by small sample sizes and heterogeneous designs.
Jack C.M
Gregory MS
