Rhyothemisresearch article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014
Photobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing
https://doi.org/10.1002/jbio.202000274
"To analyze the effects of PBMT in keratinocyte stem cells, we explored the effects of low power laser over ALDH
levels, a known detoxifying enzyme involved in the oxidation of intracellular aldehydes [50]. ALDH may have a function in the early differentiation of stem cells through its role in oxidizing retinol to retinoic acid being considered a functional marker for the stem cell population. High ALDH levels have been reported in stem cells from different tissues and to be present at high levels in cancer stem [51, 52]."
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ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis
https://doi.org/10.1016%2Fj.csbj.2023.02.045
"The American Joint Committee on Cancer (AJCC) reported that diminished ALDH2 expression was closely linked to worse overall survival (OS) in different stages of LUAD. Considerably, ALDH2 showed aberrant DNA methylation status in LUAD cancer. ALDH2 was found to be downregulated in the proteomic expression profile of several cell biology signaling pathways, particularly stem cell-related pathways. Finally, the relationship of ALDH2 activity with stem cell-related factors and immune system were reported. In conclusion, the downregulation of ALDH2, abnormal DNA methylation, and the consequent deficit of stemness signaling pathways are relevant prognostic and therapeutic markers in LUAD."
Eishi NoguchiWe have published several research articles along this line. It is one of my research projects that is purely based on my personal interest😉
Because acetaldehyde damages DNA, people (especially individual with heterozygous for this allele) shouldn't be drinking a lot. But people with homozygous for this mutation are not able to drink alcohol at all, so they never become alcoholic, which seems to be a positive effect🤔
#Alcohol #ALDH2 #Acetaldehyde #Drinking #Metabolism #Genetics
Triple IPA - 11.5% alcohol 🤔
I like this bitterness and light citrus flavor. But I feel alcohol a lot, thinking about acetaldehyde, the primary metabolite of alcohol, although my enzyme (ALDH2) that detoxifies acetaldehyde has no mutation 😉
About half of East Asian people have a mutation in this enzyme. I am looking forward to seeing our kids’ genotypes 🤔
#Alcohol #Acetaldehyde #Metabolism #Science #Genetics #AcetaldehydeDehydrogenase #ALDH2
NIH presentation, Sept 27, 2023
https://youtu.be/zLkq6a_W1nE?si=1GTVQAxEXAz4aT07
Reactive aldehydes enhance the antimicrobial effect of nitric oxide - possibly an explanation for the maintenance of ALDH2* in Asian populations.
Acetaldehyde doesn't work - so drinking alcohol won't help treat TB infection.
Warburg Effect - anaerobic glycolysis produces aldehydes (methylglyoxal) [22:12, 54:26].
#ALDH2 #NitricOxide
#Tuberculosis
#Microbiology
#Immunology #malondialdehyde #methylglyoxal #metabolism #WarburgEffect #Immunometabolism
#AldehydeHypothesis
The Aldehyde Hypothesis
Bruce Fulton"Around 8% of the world’s population has a gene variant called ALDH2*2 that impairs the body’s ability to metabolise alcohol and causes unpleasant symptoms such as flushing soon after people drink. Now, researchers have shown why this mutation also raises the risk of heart disease."
#Medicine #Alcohol #ALDH2 #Aledhydedehydrogenase
https://www.newscientist.com/article/2356421-why-gene-variant-impairing-alcohol-breakdown-raises-heart-disease-risk/?utm_term=Autofeed&utm_campaign=echobox&utm_medium=social&utm_source=Twitter#Echobox=1674915006
#Medicine #Alcohol #ALDH2 #Aledhydedehydrogenase
https://www.newscientist.com/article/2356421-why-gene-variant-impairing-alcohol-breakdown-raises-heart-disease-risk/?utm_term=Autofeed&utm_campaign=echobox&utm_medium=social&utm_source=Twitter#Echobox=1674915006
Some Long Covid symptoms, e.g., alcohol intolerance, could be due to lowered activity of aldehyde dehydrogenase, particularly ALDH2. I submitted a related hypothesis to the Patient-Led Hypothesis Generation Panel which provides background & refs (1).
Inhibition of aldehyde dehydrogenase causes lower sperm count & has been investigated as a means of male birth control (2).
1- https://docs.google.com/document/d/1XBe3xkZLUtcTUZjd07nH97jjL9QR5Vt3YS08zo7WpOY/edit?usp=sharing
2- https://www.bloomberg.com/news/features/2017-08-03/why-we-can-t-have-the-male-pill
Increasing the activity of aldehyde dehydrogenase 2 [ALDH2] could reduce markers of lipid peroxidation and improve symptoms of Long Covid
Hypothesis: Increasing the activity of aldehyde dehydrogenase 2 [ALDH2] could reduce markers of lipid peroxidation and improve symptoms of Long Covid. Rhyothemis princeps 31 October 2022 Al-Hakeim et al. [1] report increased markers of nitrosative stress and lipid peroxidation, including eleva...
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