NIH presentation, Sept 27, 2023
https://youtu.be/zLkq6a_W1nE?si=1GTVQAxEXAz4aT07

Reactive aldehydes enhance the antimicrobial effect of nitric oxide - possibly an explanation for the maintenance of ALDH2* in Asian populations.
Acetaldehyde doesn't work - so drinking alcohol won't help treat TB infection.
Warburg Effect - anaerobic glycolysis produces aldehydes (methylglyoxal) [22:12, 54:26].

#ALDH2 #NitricOxide
#Tuberculosis
#Microbiology
#Immunology #malondialdehyde #methylglyoxal #metabolism #WarburgEffect #Immunometabolism
#AldehydeHypothesis

Postdoc in Immunometabolism

University of Central Florida

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-central-florida-27778-postdoc-in-immunometabolism/?feed_id=50252

#ScienceJobs #hiring #research #Immunometabolism, #Cancer Immunotherapy, #GVHD, #Systemic Immunology
ORLANDO #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/university-of-central-florida-27778-postdoc-in-immunometabolism/?feed_id=50252

Postdoc in Immunometabolism

University of Central Florida

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-central-florida-27778-postdoc-in-immunometabolism/?feed_id=49867

#ScienceJobs #hiring #research #Immunometabolism, #Cancer Immunotherapy, #GVHD, #Systemic Immunology
ORLANDO #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/university-of-central-florida-27778-postdoc-in-immunometabolism/?feed_id=49867

>100 RNA binding proteins identified that bind to 3’UTR of cytokine mRNA (IFNg, TNF and IL2) in Human T cells.

#immunometabolism finding (Supl Tables 1 and 3)
GAPDH binding to cytokine 3’UTR in PMA/Ionomycin activated, but not untreated, Human T cells.

https://doi.org/10.1016/j.celrep.2023.112419