Summary of Metabolic Pathways: High-Yield Chart for NEET PG & USMLE
Can you instantly pinpoint where glycolysis, the TCA cycle, and the urea cycle cross paths? Master the regulatory intersections, rate-limiting steps, and critical vitamin cofactors with our integrated biochemical roadmap on mymedschool.org.
📰 "The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila"
https://doi.org/doi:10.3389/fendo.2026.1773383https://pubmed.ncbi.nlm.nih.gov/42244947/ #Metabolism #Drosophila
Frontiers | The RASA2/RASA3 ortholog RasGAP1 modulates obesity-linked phenotypes and is associated with leptin-analog signaling in Drosophila
IntroductionObesity arises from the interplay between genetic predisposition, metabolic signaling, and neural circuits that regulate feeding and energy expen...
📰 "RNA Sequencing in Adult Drosophila Females Identifies Estrogen-Related Receptor-Dependent Transcriptional Changes in Metabolism, DNA Replication, and Translation"
https://doi.org/doi:10.64898/2026.05.21.726871https://pubmed.ncbi.nlm.nih.gov/42244598/ #Metabolism #Drosophila #Adult #Larva
A flexible synthetic diet platform for Drosophila nutrigenomics - Genes & Nutrition
Background Nutrient-gene interactions are key determinants of metabolic disease phenotypes, but systematic analysis remains constrained by the labour required to generate precisely defined diets. To address this, we developed a flexible method for assembling synthetic diets for Drosophila melanogaster from individual stock solutions, enabling rapid and controlled modification of dietary composition. Results Using this approach, we generated a rational array of 51 diets in which single nutrients were varied systematically. We first showed that diets prepared using the flexible method performed comparably to standard preparation methods in wild-type flies, with similar developmental timing, survival, adult body weight, and starvation resistance. As a proof-of-concept, we then applied this dietary array to a Drosophila model of isolated sulfite oxidase deficiency, a severe metabolic disorder caused by defective sulfur amino acid catabolism. This validated previously identified nutrient-specific effects, including survival and pupariation rescue by cysteine depletion, while also revealing additional amino acid-modified diets that improved pupal survival. Conclusions This platform provides a scalable and versatile in vivo framework for systematically interrogating genotype-specific nutritional responses in Drosophila. It should facilitate the identification of diet-gene interactions relevant to metabolic disease and support broader nutritional screening across disease models.
Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival - The EMBO Journal
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrients, raising the question of how germ cell metabolism is sustained and how somatic cells ensure that sufficient resources are directed to the germline. Here, we use lineage-specific genetic manipulations and metabolite reporters to show that Drosophila somatic gonadal cells break down circulating sugars to produce and shuttle lactate to germ cells in vivo, thus sustaining their survival. Further, we uncover that somatic cells ensure the allocation of carbohydrate metabolites specifically to germ cell support and that increasing autonomous consumption of carbohydrates in somatic cells increases germ cell death. Thus, germ cell survival depends on functional metabolic compartmentalisation within gonadal somatic support cells.
#ego #ego #me #me
LDLR-3′UTR Deletions Identified as a Genetic Cause of Hypobetalipoproteinemia: Evidence From Familial and Population-Based Studies
https://www.ahajournals.org/doi/10.1161/ATVBAHA.125.324245
#ldl #utr #metabolism #lipid #indel #sv
📰 "Microbiome Integrity Protects Against Glial-Mediated Tau and Amyloid Pathology Through Circadian and Autophagy Homeostasis"
https://doi.org/doi:10.64898/2026.05.20.726549https://pubmed.ncbi.nlm.nih.gov/42239356/ #Circadian #Drosophila #Metabolism
Frontiers | Altered mitochondrial functionality in metabolic disorders: insights from Drosophila studies
The pathophysiological association between obesity and type 2 diabetes (T2D) increasingly highlights the central role of mitochondrial dysfunction. As critic...
📰 "Neuronal Syndecan reduction modulates age- and sex-specific changes in sleep architecture and metabolic remodeling in Drosophila melanogaster"
https://doi.org/doi:10.1016/j.mad.2026.112207https://pubmed.ncbi.nlm.nih.gov/42235612/ #DrosophilaMelanogaster #Drosophila #Metabolism #Sleep
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