Ars Technica NewsJun 26, 2025
Changing one gene can restore some tissue regeneration to mice https://arstechni.ca/Z4HM #regeneration #retinoicacid #Science #Biology #Mice
Changing one gene can restore some tissue regeneration to mice

Signaling from retinoic acid appears to be key to getting mice to regrow ear damage.

Ars Technica
Matt WillemsenJan 21, 2024
Just One Molecule Allows Us to See Millions More Colors Than Our Pets
https://www.sciencealert.com/just-one-molecule-allows-us-to-see-millions-more-colors-than-our-pets #color #vision #red #opsin #thyroid #RetinoicAcid
Just One Molecule Allows Us to See Millions More Colors Than Our Pets

It's pretty hard to imagine the world through someone else's eyes, especially different animals.

ScienceAlert
Hao YinJan 3, 2023

#Angiocrine Lung #Alveologenesis

Cyp26b1, catabolizing #RetinoicAcid, is #EndothelialCell-restricted in 🐭 emb Lung+Kidney

Cyp26b1 KO->
⏬AT1 fate of Sox9+ distal airway epithelial progenitors
⏫septa thickness
⏬Airspace

@ondinecleaver2022 @Dev_journal 2020
https://journals.biologists.com/dev/article/147/4/dev181560/223218/Cyp26b1-is-an-essential-regulator-of-distal-airway

Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development

Highlighted Article: Loss of Cyp26b1 results in neonatal lethality due to failure of distal lung epithelial differentiation, with increased AT2 and decreased AT1 cell types.

The Company of Biologists
Show threadRhyothemisNov 29, 2022

@jaclynmacrae

Some Long Covid symptoms, e.g., alcohol intolerance, could be due to lowered activity of aldehyde dehydrogenase, particularly ALDH2. I submitted a related hypothesis to the Patient-Led Hypothesis Generation Panel which provides background & refs (1).

Inhibition of aldehyde dehydrogenase causes lower sperm count & has been investigated as a means of male birth control (2).

1- https://docs.google.com/document/d/1XBe3xkZLUtcTUZjd07nH97jjL9QR5Vt3YS08zo7WpOY/edit?usp=sharing

2- https://www.bloomberg.com/news/features/2017-08-03/why-we-can-t-have-the-male-pill

#LongCovid #ALDH2 #RetinoicAcid #spermatogenesis

Increasing the activity of aldehyde dehydrogenase 2 [ALDH2] could reduce markers of lipid peroxidation and improve symptoms of Long Covid

Hypothesis: Increasing the activity of aldehyde dehydrogenase 2 [ALDH2] could reduce markers of lipid peroxidation and improve symptoms of Long Covid. Rhyothemis princeps 31 October 2022 Al-Hakeim et al. [1] report increased markers of nitrosative stress and lipid peroxidation, including eleva...

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