RhyothemisPhotobiomodulation therapy drives massive epigenetic histone modifications, stem cells mobilization and accelerated epithelial healing
https://doi.org/10.1002/jbio.202000274
"To analyze the effects of PBMT in keratinocyte stem cells, we explored the effects of low power laser over ALDH
levels, a known detoxifying enzyme involved in the oxidation of intracellular aldehydes [50]. ALDH may have a function in the early differentiation of stem cells through its role in oxidizing retinol to retinoic acid being considered a functional marker for the stem cell population. High ALDH levels have been reported in stem cells from different tissues and to be present at high levels in cancer stem [51, 52]."
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ALDH2 as a potential stem cell-related biomarker in lung adenocarcinoma: Comprehensive multi-omics analysis
https://doi.org/10.1016%2Fj.csbj.2023.02.045
"The American Joint Committee on Cancer (AJCC) reported that diminished ALDH2 expression was closely linked to worse overall survival (OS) in different stages of LUAD. Considerably, ALDH2 showed aberrant DNA methylation status in LUAD cancer. ALDH2 was found to be downregulated in the proteomic expression profile of several cell biology signaling pathways, particularly stem cell-related pathways. Finally, the relationship of ALDH2 activity with stem cell-related factors and immune system were reported. In conclusion, the downregulation of ALDH2, abnormal DNA methylation, and the consequent deficit of stemness signaling pathways are relevant prognostic and therapeutic markers in LUAD."