Vaginal Estrogen Show and Tell
https://youtu.be/l9OrOIVM5xY?si=_nk9vhEvLkIG1PGD

#estrogen #estradiol #health #UTI #aging #menopause #HRT #medicine #2dayIwatched #BladderInfection

Dark Days and Bright Nights Associated with a Dose-Dependent Increase in Mortality
https://youtu.be/UceHiFblPUs?si=z3onF7OPc7_CkGja

journal article:
Brighter nights and darker days predict higher mortality risk: A prospective analysis of personal light exposure in 88,000 individuals
https://www.pnas.org/doi/epub/10.1073/pnas.2405924121

~

I had recently posted that I wished there were more epidemiological studies that tracked light exposure / time outdoors:
https://zeroes.ca/@Rhyothemis/113216485138966187

#2dayIwatched #LightExposure #photobiology #chronobiology
#medicine #health #photobiomodulation

today I watched:

Brain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain
https://youtu.be/9Z4Eg1dtyOc?si=MPMcrFYYj2De6u9Y

Very interesting and pretty technical. I will have to re-watch.

[37:00] - #POTS #MCAS #hypermobility #LongCovid

#2dayIwatched #ChronicPain #psychiatry #neuroscience #rapamycin #ketamine

today I watched:

Disrupting Health Care Using Deep Data and Remote Monitoring: Michael Snyder, Ph.D.
https://www.youtube.com/live/Mv7aBcqcKsQ?si=gF33tYL6smgfwhp7

Lots of interesting points, esp.

- [5:28] avg. human body temp. is 97.5 deg. F ; variation in baseline make the definition of 'fever' problematic

- [37:35] blood oxygen drops during airplane flights
(I knew that before watching this video, but did not know a few decades ago when pregnant)

#biology #medicine #biomarkers
#2dayIwatched

today I watched:

Karsenty: Osteocalcin and the Regulation of Muscle Mass

https://youtu.be/3bDwBRM2GKE?si=_NIbnkUi5l-8XFeC

older video, uploaded 19 Sep 2012

- bone is an endocrine tissue
- effects on aging
- undercaboxylated osteocalcin regulates insulin secretion, insulin sensitivity, testosterone secretion
- undercarboxylated osteocalcin promotes myoblast proliferation & muscle regeneration
- osteocalcin KO mice have decreased muscle oxidative capacity [10:40]
- study conducted on female mice to minimize effects of testosterone on muscle
- Esp inhibits osteocalcin by carboxylating it
- 21:31 summary slide
- credit to postdoc researcher Kathrin Laue
- presented by Gerard Karnsenty

#2dayIWatched #aging #BoneHealth #MuscleMass
#osteocalcin #biology #physiology

today I watched:

Is Bryan Johnson's Longevity Protocol Worth the Hype? | Plant Chompers
uploaded 27 Sept 2024

https://youtu.be/-JfdaZAkZwc?si=fTiqjolA5IwoKpEV

comments:

re: 5:40 Type of exercise for longevity

People usually play tennis outdoors. It would be nice to see 'time spent outdoors' and 'timing of outdoor light exposure' as a variables in more epidemiological studies. Outdoor time/natural sunlight exposure has an effect on circadian rhythm entrainment (morning exposure) and on the development of myopia in children (afternoon exposure). Perhaps it also has an effect on aging and age-related diseases. Perhaps fitness trackers could be modified to gather these data.

According to the study*, they 'Adjusted for age, sex, weekly volume of all LTPAs, smoking, education, income, drinking habits, and diabetes'. LTPA = leisure time physical activity. I would like to see an adjustment for time spent outdoors. I'm also wondering if playing tennis increases grip strength.

Of course, everything that turns up on search is about how tennis players can improve their grip strength - not the other way around.

~
re: supplements
there's some compelling epidemiological evidence on glucosamine and longevity; it is derived from shellfish, so not for people with shellfish allergy

* Various Leisure-Time Physical Activities Associated With Widely Divergent Life Expectancies: The Copenhagen City Heart Study
https://www.usta.com/es/content/dam/usta/sections/northern/pdf/hainline-interview/tennis-benefits-mayo.pdf

#Aging #longevity #2dayIwatched

today I watched:

The Dog Aging Project that aims at Helping Dogs Live Longer
https://youtu.be/YwmkGLqi018?si=rmOcMSpsWsWUCD-H

I was really disappointed about the NIH funding cut - this project is important for both dog and human health. As Dr Kaeberlein points out, it's also great in terms of public relations for geoscience and science in general.

~

It's an open science project - the data are available to qualified researchers.

#DogAgingProject #Dogs #health #aging #geroscience #OpenScience #2DayIWatched

today I watched:

How Alzheimer's mutates the immune system | nature video

https://youtu.be/o_dbdhwNbig?si=P53kD4ckA45YXKRL

5 min. interview with David Gate on CXCR3 expressing peripheral T cells and Alzheimer disease.

~

I wonder if thiamine deficiency increases CXCR3 expression?

#2dayIwatched #Alzheimers
#NeurodegenerativeDiseases
#Tcells #BrainHealth #immunology #neuroscience