RhyothemisSep 29, 2024

today I watched:

Karsenty: Osteocalcin and the Regulation of Muscle Mass

https://youtu.be/3bDwBRM2GKE?si=_NIbnkUi5l-8XFeC

older video, uploaded 19 Sep 2012

- bone is an endocrine tissue
- effects on aging
- undercaboxylated osteocalcin regulates insulin secretion, insulin sensitivity, testosterone secretion
- undercarboxylated osteocalcin promotes myoblast proliferation & muscle regeneration
- osteocalcin KO mice have decreased muscle oxidative capacity [10:40]
- study conducted on female mice to minimize effects of testosterone on muscle
- Esp inhibits osteocalcin by carboxylating it
- 21:31 summary slide
- credit to postdoc researcher Kathrin Laue
- presented by Gerard Karnsenty

#2dayIWatched #aging #BoneHealth #MuscleMass
#osteocalcin #biology #physiology

- YouTube

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Show threadRhyothemisNov 16, 2022

critiques of ^ Jarlsberg cheese study:
https://www.sciencemediacentre.org/expert-reaction-to-study-looking-at-daily-jarlsberg-cheese-versus-camembert-and-measures-of-bone-thinning/

Steenson's critique seems fair overall.
In any case this study brought 1,4-hihydroxy-naphthoic acid ( #DHNA ) to my attention.

Diabetic or not, lowering glycation (#HbA1c) seems a good thing. Interesting effects reported on serum Ca & Mg, also. #Osteocalcin is linked to brain health as well as bone health.

I'm doing my own n=1 trial of Jarlsberg #cheese - only ~20g/day, tho. (57g/day in study)

#NaturalProducts #FunctionalFoods

expert reaction to study looking at daily Jarlsberg cheese (versus Camembert) and measures of bone thinning | Science Media Centre