Mastodawn

Why is excess vitamin D dangerous? #vitamind #hypervitaminosis #vitamins #cholecalciferol ... Continue to: https://www.facebook.com/reel/27061088746852759/

Wolfgang Hagen 5d ago

Es ist in meiner klinischen Erfahrung kaum zu verhindern, dass *jeder* mit einem Sternchen beim Vitamin D auf dem Laborbefund eine Substitution bekommt.

Große Metaanalyse zeigt jetzt, dass die Einnahme von Kalzium, #VitaminD oder einer Kombination aus beiden so gut wie keinen Nutzen zur Vorbeugung von Knochenbrüchen oder Stürzen hat.

(Wichtig: Personen mit einer nachgewiesenen Osteoporose oder andere Personengruppen mit einer speziellen Indikation für Vitamin D wurden hier nicht inkludiert.)

> Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

https://www.bmj.com/content/393/bmj-2025-088050

Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis

Objective To assess the effect of calcium, vitamin D, or combined supplementation on fractures and falls in adults. Design Systematic review and meta-analysis. Data sources Trials included in systematic reviews from 2014, three databases (Medline, Embase, CENTRAL) to 19 February 2025, clinical trial registries, abstracts from scientific meetings, and references from included studies. Eligibility criteria Randomised controlled trials comparing calcium, vitamin D, or combined supplementation with placebo or no treatment in adults (≥18 years) not receiving drug treatment for osteoporosis. Data extraction and synthesis The primary outcome was the risk of any fracture. Secondary outcomes included the risk of hip fracture, non-vertebral fracture, vertebral fracture, and falling, as well as the total number of falls. Pairs of reviewers independently screened trials, extracted data, and assessed risk of bias using the second version of Cochrane’s risk of bias tool. Findings were synthesised using random effects meta-analyses and appraised using Grading of Recommendations Assessment, Development and Evaluation, with application of thresholds for absolute effects considered important. Results This review included 69 trials involving 153 902 participants. Participants in most of the trials were community dwelling (87%) and not at high risk of fractures or falls (73%). For the primary outcome of any fracture, little to no effect was found from use of calcium supplements (11 trials, 9067 participants; risk ratio 0.91, 95% confidence interval 0.81 to 1.01; moderate certainty), vitamin D supplements (36 trials, 92 045 participants; 1.00, 0.95 to 1.06; high certainty), or combined supplementation (15 trials, 51 126 participants; 0.91, 0.84 to 0.99; high certainty). Calcium, vitamin D, or combined supplementation appeared to have little to no effect on other fracture and fall outcomes, based largely on moderate to high certainty of evidence. The findings remained robust after an extensive exploration of heterogeneity across multiple subgroup analyses. Evidence for high risk patients or those requiring residential care was limited for many outcomes for calcium monotherapy and for combined supplementation. Conclusion Based on absolute risk reductions and thresholds considered clinically meaningful, this review found little to no benefits from use of calcium, vitamin D, or combined supplementation on the prevention of fractures and falls. Systematic review registration PROSPERO CRD42023483915. All the data are available on Borealis at <https://doi.org/10.5683/SP3/N98FVW>. If you experience difficulties accessing the data or require clarification, please contact the corresponding author.

The BMJ

Dining and Cooking 6d ago

Vitamin D and calcium may not support bone health as much as thought: study – National

A recently released study by the British Medical Journal (BMJ) is casting doubt on the longstanding belief that calcium and vitamin D intake can help prevent bone fra…
#dining #cooking #diet #food #Nutrition #BritishMedicalJournal #calcium #canada #consumer #health #nutrition #vitamind
https://www.diningandcooking.com/2671433/vitamin-d-and-calcium-may-not-support-bone-health-as-much-as-thought-study-national/

Global News Jun 4

Vitamin D and calcium may not support bone health as much as thought: study
Seventy-three per cent of participants were 'not at high risk of fractures or falls,' with calcium, vitamin D or combined supplements having 'little to no effect on fractures.'
#Canada #Consumer #Health #BritishMedicalJournal
https://globalnews.ca/news/11888607/vitamin-d-and-calcium-health-study/

Global News National Jun 4

Vitamin D and calcium may not support bone health as much as thought: study
Seventy-three per cent of participants were 'not at high risk of fractures or falls,' with calcium, vitamin D or combined supplements having 'little to no effect on fractures.'
#Canada #Consumer #Health #BritishMedicalJournal
https://globalnews.ca/news/11888607/vitamin-d-and-calcium-health-study/

Global News Health Jun 4

Vitamin D and calcium may not support bone health as much as thought: study
Seventy-three per cent of participants were 'not at high risk of fractures or falls,' with calcium, vitamin D or combined supplements having 'little to no effect on fractures.'
#Canada #Consumer #Health #BritishMedicalJournal
https://globalnews.ca/news/11888607/vitamin-d-and-calcium-health-study/

Global News Canada Jun 4

Vitamin D and calcium may not support bone health as much as thought: study
Seventy-three per cent of participants were 'not at high risk of fractures or falls,' with calcium, vitamin D or combined supplements having 'little to no effect on fractures.'
#Canada #Consumer #Health #BritishMedicalJournal
https://globalnews.ca/news/11888607/vitamin-d-and-calcium-health-study/

Blog & Podcast by Pepik Hipik & Knižní kočka May 30

K čemu je dobrý vitamín D? V jakém množství ho suplementovat? A jaký vliv má v tom všem sluneční záření?

V 84. epizodě do podcastu MEDICÍNA SRDCEM zavítal přednosta Ústavu farmakologie a toxikologie na LFP prof. PharmDr. Radek Kučera, Ph.D. […]

https://pepikhipik.com/2026/05/30/k-cemu-je-dobry-vitamin-d-v-jakem-mnozstvi-ho-suplementovat-a-jaky-vliv-ma-v-tom-vsem-slunecni-zareni/

All Scientifical May 29

What categories of people are prone to cholecalciferol hypovitaminosis? #cholecalciferol #vitamind ... Continue to: https://www.facebook.com/reel/865441353272342/

KillBait News May 23

Study Shows Vitamin D2 Supplements May Reduce Beneficial Vitamin D3 Levels

📰 Original title: Scientists warn popular vitamin D supplement may have a "previously unknown" downside

🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️

View full AI summary: https://en.killbait.com/study-shows-vitamin-d2-supplements-may-reduce-beneficial-vitamin-d3-levels.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world

#health #vitamind #supplements #immunesystem

Study Shows Vitamin D2 Supplements May Reduce Beneficial Vitamin D3 Levels

A new study from the University of Surrey, in collaboration with the John Innes Centre and Quadram Institute Bioscience, has raised concerns about vitamin D2 supplements. Researchers found that taking vitamin D2, a common form of the supplement derived from plants, can actually lower the body's levels of vitamin D3, which is the form naturally produced through sunlight exposure and considered more effective for raising overall vitamin D status. The meta-analysis of randomized controlled trials, published in Nutrition Reviews, showed consistent drops in vitamin D3 concentrations among participants using D2 supplements compared to control groups. Vitamin D is crucial for bone health, immune function, and overall wellness, particularly in regions like the UK where winter sunlight is insufficient for natural production. The UK government recommends 10 micrograms daily, especially from October to March. Lead researcher Emily Brown emphasized that while supplements are important during low-sunlight periods, D2 may not be the optimal choice for everyone. The study also references prior research indicating that vitamin D3 uniquely supports the type I interferon signaling system, providing a stronger first line of defense against viruses and bacteria. Experts suggest prioritizing vitamin D3 supplements or ensuring better access to plant-based D3 sources. This finding could influence future public health guidelines on vitamin D fortification and supplementation strategies to better combat widespread deficiency. Professors involved highlighted the need for more research into the distinct roles of D2 and D3 in immune health and called for innovations in food to improve nutrient density. Overall, the research encourages individuals to consider personal needs when choosing supplements but points toward D3 as potentially superior for most people.

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