Medical Supplementation: Fracture Prevention Claims Disputed
New BMJ study finds calcium and Vitamin D supplements don't reduce fracture risk for adults. What does this mean for your bone health?
#BoneHealth, #Supplements, #BMJ, #FracturePrevention, #VitaminD
https://newsletter.tf/calcium-vitamin-d-supplements-no-fracture-benefit/
A new study in the BMJ found that taking calcium and Vitamin D pills does not significantly lower the risk of fractures for most adults. This is different from what many people believed.
#BoneHealth, #Supplements, #BMJ, #FracturePrevention, #VitaminD
https://newsletter.tf/calcium-vitamin-d-supplements-no-fracture-benefit/
K čemu je dobrý vitamín D? V jakém množství ho suplementovat? A jaký vliv má v tom všem sluneční záření?
V 84. epizodě do podcastu MEDICÍNA SRDCEM zavítal přednosta Ústavu farmakologie a toxikologie na LFP prof. PharmDr. Radek Kučera, Ph.D. […]
Study Shows Vitamin D2 Supplements May Reduce Beneficial Vitamin D3 Levels
📰 Original title: Scientists warn popular vitamin D supplement may have a "previously unknown" downside
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️
View full AI summary: https://en.killbait.com/study-shows-vitamin-d2-supplements-may-reduce-beneficial-vitamin-d3-levels.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world
A new study from the University of Surrey, in collaboration with the John Innes Centre and Quadram Institute Bioscience, has raised concerns about vitamin D2 supplements. Researchers found that taking vitamin D2, a common form of the supplement derived from plants, can actually lower the body's levels of vitamin D3, which is the form naturally produced through sunlight exposure and considered more effective for raising overall vitamin D status. The meta-analysis of randomized controlled trials, published in Nutrition Reviews, showed consistent drops in vitamin D3 concentrations among participants using D2 supplements compared to control groups. Vitamin D is crucial for bone health, immune function, and overall wellness, particularly in regions like the UK where winter sunlight is insufficient for natural production. The UK government recommends 10 micrograms daily, especially from October to March. Lead researcher Emily Brown emphasized that while supplements are important during low-sunlight periods, D2 may not be the optimal choice for everyone. The study also references prior research indicating that vitamin D3 uniquely supports the type I interferon signaling system, providing a stronger first line of defense against viruses and bacteria. Experts suggest prioritizing vitamin D3 supplements or ensuring better access to plant-based D3 sources. This finding could influence future public health guidelines on vitamin D fortification and supplementation strategies to better combat widespread deficiency. Professors involved highlighted the need for more research into the distinct roles of D2 and D3 in immune health and called for innovations in food to improve nutrient density. Overall, the research encourages individuals to consider personal needs when choosing supplements but points toward D3 as potentially superior for most people.
Study Shows Vitamin D2 Supplements May Reduce Beneficial Vitamin D3 Levels
📰 Original title: Scientists warn popular vitamin D supplement may have a "previously unknown" downside
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️
View full AI summary: https://en.killbait.com/study-shows-vitamin-d2-supplements-may-reduce-beneficial-vitamin-d3-levels.html?utm_source=mastodon_social&utm_medium=social&utm_campaign=killbait.mastodon_social
A new study from the University of Surrey, in collaboration with the John Innes Centre and Quadram Institute Bioscience, has raised concerns about vitamin D2 supplements. Researchers found that taking vitamin D2, a common form of the supplement derived from plants, can actually lower the body's levels of vitamin D3, which is the form naturally produced through sunlight exposure and considered more effective for raising overall vitamin D status. The meta-analysis of randomized controlled trials, published in Nutrition Reviews, showed consistent drops in vitamin D3 concentrations among participants using D2 supplements compared to control groups. Vitamin D is crucial for bone health, immune function, and overall wellness, particularly in regions like the UK where winter sunlight is insufficient for natural production. The UK government recommends 10 micrograms daily, especially from October to March. Lead researcher Emily Brown emphasized that while supplements are important during low-sunlight periods, D2 may not be the optimal choice for everyone. The study also references prior research indicating that vitamin D3 uniquely supports the type I interferon signaling system, providing a stronger first line of defense against viruses and bacteria. Experts suggest prioritizing vitamin D3 supplements or ensuring better access to plant-based D3 sources. This finding could influence future public health guidelines on vitamin D fortification and supplementation strategies to better combat widespread deficiency. Professors involved highlighted the need for more research into the distinct roles of D2 and D3 in immune health and called for innovations in food to improve nutrient density. Overall, the research encourages individuals to consider personal needs when choosing supplements but points toward D3 as potentially superior for most people.
A small mouse study found that supplemental vitamin D reduced neuroinflammation and reduced cell death in the hippocampus and prefontal cortex of offspring of female mice who were given propofol (a general anaesthetic) during pregnancy.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0349784
#Science #Pregnancy #Anaesthesia #Propofol #VitaminD #BrainDamage
Background Maternal propofol can induce neurotoxicity in the developing brain. Vitamin D modulates neurotrophin and neuromediator synthesis, reduces neuroinflammation and neuroapoptosis. The present study examined whether vitamin D could mitigate maternal propofol induced neurotoxicity in the offspring. Method Twenty pregnant mice were randomly divided into four groups. During the pregnancy, the groups designated as D and PD were given intraperitoneal vitamin D, while the groups labelled as P and C received 1 ml of saline. On the 14th day of pregnancy, groups P and PD received 200 mg kg-1 of propofol intraperitoneally. Newborn mice from the aforementioned groups were included in the study. The hippocampus and the prefrontal cortex were examined by immunohistochemistry at two postnatal ages: 7 and 45 days (PN7 and PN45). A battery of behavioural assessments was conducted using open field and elevated plus maze tests to evaluate potential alterations at PN45. Results Vitamin D reduced the expression of inflammatory and apoptotic factors induced by propofol, such as TNF-α (group P versus group PD: 0.79 (0.76–0.81) versus 0.36 (0.34–0.39), %95 CI; p < 0.001), Bax (group P versus group PD: 0.72 (0.69–0.74) versus 0.52 (0.5–0.54), %95 CI; p < 0.001) in the hippocampus in PN7. The administration of vitamin D resulted in enhanced expression of anti-apoptotic and neuroprotective proteins, such as Bcl-2 (group P versus group PD: 0.3 (0.27–0.33) versus 0.55 (0.53–0.57), %95 CI; p < 0.001) in the hippocampus in PN7. These changes also occurred in the hippocampus in PN45 and the prefrontal cortex in PN7 and PN45. No significant differences were identified in the behavioural tests between the groups. Conclusion Vitamin D treatment during pregnancy could prevent neurotoxicity in the offspring of mice exposed to propofol.
Nun ist er wohl da, der sonnenreiche Sommer. Ab morgen wird es zumindest bei uns im Südwesten sonnig und heiß, bei einem UV-Index ab 7.
Zeit, meinen Blog-Post zum Thema „Sonnenschutz“ zu tröten:
https://www.luluas-cafe.de/blog/sonnenschutz
#Sonnenschein #Sonne #Sommer #Sonnenbrand #UVStrahlung #VitaminD
An observational study of 184 women who underwent breast cancer surgery, half of whom had vitamin D deficiency, found that those with vitamin D deficiency experienced more post-operative pain and self-administered more pain medication.
Summary: https://www.sciencedaily.com/releases/2026/05/260519224308.htm
Original paper: https://rapm.bmj.com/content/early/2026/05/04/rapm-2025-107495
Low vitamin D levels could be quietly making breast cancer surgery recovery far more painful. In a new study, patients deficient in vitamin D were three times more likely to experience moderate to severe pain after mastectomy surgery and ended up using significantly more opioid medication to cope. Researchers say vitamin D may help regulate how the body processes pain through its effects on inflammation and the immune system.
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