🤯 What if most “biological insights” are just mixed-up signals we never untangled?

🔗 Integrative Learning of Disentangled Representations from Single-Cell RNA-Sequencing Datasets. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0015

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#SystemsBiology #Genomics #Bioinformatics #ComputationalBiology #AIinBiology #SingleCell #MachineLearning #DataScience #LifeSciences

🧬 Can we map the cascade of gene activity that guides cells through differentiation?

🔗 Pseudotimecascade Visualizes Gene Expression Cascade in Pseudotime Analysis. Computational and Structural Biotechnology Journal (CSBJ). https://spj.science.org/doi/epdf/10.34133/csbj.0007

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#SingleCell #Genomics #Bioinformatics #SystemsBiology #GeneExpression #ComputationalBiology

[Edit] I think I finally have some winners WITH cell identities, though I had to dig for that part. Thanks!

Anyone working in #Genomics #SingleCell #RNASeq aware of a good data source for human kidney single-cell data that has *labeled* cell types.

We have a #GWAS that the target tissue would be kidneys. I'm stuck doing cell type analyses until I can find some labeled cell type data to connect back to the association data.

Pipeline release! nf-core/scnanoseq v1.2.2 - nf-core/scnanoseq v1.2.2 - Thallium Tiger!

Please see the changelog: https://github.com/nf-core/scnanoseq/releases/tag/1.2.2

#10xgenomics #longreadsequencing #nanopore #rnaseq #scrnaseq #singlecell #nfcore #openscience #nextflow #bioinformatics

Pipeline release! nf-core/pixelator v3.0.1 - nf-core/pixelator 3.0.1!
Pipeline to generate Molecular Pixelation data with Pixelator (Pixelgen Technologies AB)
Please see the changelog: https://github.com/nf-core/pixelator/releases/tag/3.0.1

#molecularpixelation #pixelator #pixelgentechnologies #proteins #singlecell #singlecellomics #nfcore #openscience #nextflow #bioinformatics

🔬 Spatial Transcriptomics - Feb 2026

• CLIM-TIME maps 7 TME subtypes linked to T cell therapy response
• Kupffer cells promote immune evasion in liver metastases
• CD276 drives chemoresistance in pancreatic cancer
• T cell activation correlates with better survival in glioblastoma
• mFISH3D visualizes multiple mRNA types in intact mouse brains
• RNA-modifying proteins emerge as potential therapeutic targets

https://pir.sh/9XygJ0Xd3w

#SpatialTranscriptomics #CancerBiology #SingleCell #Biology

TelomereHunter2 Workshop in Heidelberg! 🔬✨

Ready to analyze telomere maintenance mechanisms in cancer, immunology, or aging?

📅 Date: April 14, 2026
🏫 Location: Im Neuenheimer Feld 242, HD
🛠️ Tool: TelomereHunter2 (supports WGS, Single-cell, and more!)

From theoretical background to hands-on results interpretation, we’ve got you covered.

Register here: https://www.denbi.de/training-courses-2026/2059-telomere-research-telomerehunter2-workshop

#Bioinformatics #Telomere #AgingResearch #SingleCell

Pipeline release! nf-core/pixelator v3.0.0 - nf-core/pixelator 3.0.0!
Pipeline to generate Molecular Pixelation data with Pixelator (Pixelgen Technologies AB)
Please see the changelog: https://github.com/nf-core/pixelator/releases/tag/3.0.0

#molecularpixelation #pixelator #pixelgentechnologies #proteins #singlecell #singlecellomics #nfcore #openscience #nextflow #bioinformatics

#Genetics #Genomics #Bioinformatics

Anyone have any favorites for R packages to do cell-type classification of #PBMCs in #SingleCell #RNASeq? I've used scGate with manual marker decisions in the past, but it's been a while since I've had to do it so I wasn't sure how the landscape had changed.