Mastodawn

I have had too many friends with cancer, and this is what motivated me to build Fusion Oncology. I hit a major breakthrough at the University of Pittsburgh during my Master's thesis, where I developed a novel method to fuse XGBoost and BERT into a singular, high-complexity intelligence model. I am now turning my full attack on cancer with these same architectures. I realized that while I've spent my life reverse engineering machines to hunt for vulnerabilities in silicon, the most complex and broken binary on the planet is the human cell. For too long, "precision oncology" has been stalled by siloed models and a growing mountain of genomic noise. This project changes that by treating cancer as a technical exploit.

This isn't just another script; it is a 19,000+ line open-source framework, bulletproofed with 305 tests, that achieves true multi-modal integration. By PCA-compressing 768-dimensional DNABERT-2 sequence embeddings and weighting them by the drug sensitivity of 1,002 GDSC cell lines, I've built a single, jointly-learned XGBoost classifier. This fusion creates the Fusion Index, calculated as Importance×Instability×1000, a definitive metric for therapeutic vulnerability validated against 62 COSMIC driver genes. This isn't just a list of targets; it's a path from raw drug sensitivity data to a life-saving treatment roadmap in one click.

@kaggle Notebook: https://www.kaggle.com/code/mytechnotalent/fusion-oncology

GitHub Code:
https://github.com/mytechnotalent/fusion_oncology

#CancerResearch #PrecisionMedicine #ArtificialIntelligence #OpenSource #Genomics #DrugDiscovery #Kaggle

Marianne 1d ago

Many years ago, I wrote a sciencey Valentine's day post.
Here tis.

It's really really old. I'm getting that way.
https://noodlemaz.wordpress.com/2011/02/14/3/

#science #angiogenesis #tumoutBiology #cancerBiology #cancerResearch #research #PhDChat #PhD #valentines #valentinesday #scicomm #ScienceCommunication

<3

[I pin this post to the top for a little while in February most years now; some of it (not the important stuff) is obviously out of date!] OK I’ve mostly avoided mentioning anything about tod…

Purely a figment of your imagination

Kevin Thomas ✅2d ago

Comprehensive precision oncology platform fusing XGBoost feature importance, DNABERT-2 sequence embeddings, multi-omics integration, clinical evidence aggregation, and computational pharmacology to identify, validate, and prioritise high-impact therapeutic strategies for cancer. #PrecisionOncology #Bioinformatics #DrugDiscovery #CancerResearch https://github.com/mytechnotalent/fusion_oncology

ProgressNow New Mexico 4d ago

There are a number of ways RFK Jr. is making our cities/towns less safe, but creating confusion about basic public health is the thing that ties it all together...

“If lots of people believe it and it’s moving public health, we as NIH have an obligation, again, to treat it seriously"

TY @STAT for the important coverage: https://newsie.social/@STAT/116047162664608497

#PublicHealth #CancerResearch

Headlines Africa 5d ago

Africa: No, Beetroot Juice Won't 'Kill Cancer Cells in 42 Days': [Africa Check] IN SHORT: Don't believe social media posts claiming that drinking beetroot juice can kill cancer cells within 42 days. Cancer is a serious medical condition that requires diagnosis and treatment by trained healthcare professionals, not home remedies or dietary drinks. http://newsfeed.facilit8.network/TQtqkH #CancerAwareness #BeetrootJuice #HealthMyths #MedicalAdvice #CancerResearch