Reverse Aging? This Scientist Has The Answer!

Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

Follow @biohackingpathway for more

#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

Adaptation to Stress: Enhanced Tolerance to Cd2+ and Radiomimetics in Arabidopsis from the Chornobyl Zone - #Arabidopsisthaliana #DNAdamage #heavymetals #radiomimetics #genomicstability #planttolerance #Chornobyl #Cd #ChornobylZone - https://link.springer.com/article/10.3103/S0095452725050032
Adaptation to Stress: Enhanced Tolerance to Cd2+ and Radiomimetics in Arabidopsis from the Chornobyl Zone - Cytology and Genetics

Abstract Investigation of A. thaliana accessions from the Chornobyl zone revealed their increased tolerance to cadmium (Cd2+) and radiomimetics (bleomycin/zeocin). Thus, seedlings of the Chornobyl accession Che07 demonstrated reduced inhibition of root growth under Cd-induced stress. It was observed for the first time that zeocin mainly affects the cells of the root meristem, whereas Cd2+ predominantly affects cells of the elongation zone. This differential response may be due to variations in the stages of cell development, the specificity of genotoxic agents, and the activity of defense mechanisms in different growth zones of the root. Analysis of DNA damage and repair capacity revealed a rapid (within 3 min) activation of repair mechanisms in the Chornobyl A. thaliana accessions Che5 and Che07 after treatment with radiomimetic. Increased expression of the cyclin gene CycB2;1 and decreased expression of the CDKG1 kinase gene after treatment with bleomycin indicate changes in the regulation of the cell cycle, specifically an arrest at the G2 phase. Such an adaptive response likely functions to suppress mitotic entry, which prevents the transfer of damaged DNA to daughter cells. In A. thaliana accessions from the Chornobyl zone, the activation of specific antioxidant enzymes was observed, which counteracts oxidative stress and damage to the genome. It is assumed that A. thaliana from the Chornobyl zone develop unique mechanisms of adaptation to environmental stress and DNA damage, caused by ionizing agents. Investigating the tolerance of plants to ionizing radiation and heavy metals is important for the development of phytoremediation strategies as well as biotechnologies to improve resistance to other abiotic stress factors.

SpringerLink

Reverse Aging? This Scientist Has The Answer!

Explore the science of aging and discover how DNA damage and stress accelerate the aging process. We investigate the impact of broken chromosomes and cellular stress on aging in mice, revealing groundbreaking insights into how we age.

Follow @biohackingpathway for more

#aging #DNAdamage #cellularstress #health #science #research #longevity #miceexperiments #biologicalaging #wellnesslife #wellnesshotel #wellbeingjourney #wellbeingwarrior #antiaging

Folate Deficiency: DNA Damage Risk - Rhonda Patrick on DOAC

#dnadamage #insulinsignaling #folate #longevity

What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability

https://geekoo.news/how-protein-droplets-shield-dna-from-catastrophic-errors/

How Protein Droplets Shield DNA From Catastrophic Errors | Geekoo

A newly discovered function of the Nup98 protein reveals how cells escort fragile DNA out of danger zones — offering clues for cancer therapy and anti-aging science.

Geekoo
The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance - PubMed

Chromothripsis describes the catastrophic shattering of mis-segregated chromosomes trapped within micronuclei. Although micronuclei accumulate DNA double-strand breaks and replication defects throughout interphase, how chromosomes undergo shattering remains unresolved. Using CRISPR-Cas9 screens, we …

PubMed

[PDF] National Association of Marine Laboratories
Position Paper

Scientific opposition to Japan’s planned release of over 1.3 million tons of radioactively contaminated water from the #FukushimaDaiIchi #NuclearPowerPlant
disaster into the #PacificOcean.

December 2022

“The National Association of Marine Laboratories (#NAML), an organization of more than
100 member laboratories, opposes Japan’s plans to begin releasing over 1.3 million tons of radioactively contaminated water from the Fukushima-Daiichi Nuclear Power Plant into the Pacific Ocean commencing in 2023. This opposition is based on the fact that there is a lack of adequate and accurate scientific data supporting Japan’s assertion of safety.

"Furthermore, there is an abundance of data demonstrating serious concerns about releasing radioactively contaminated water.

“The Pacific Ocean is the largest continuous body of water on our planet, containing the greatest biomass of organisms of ecological, economic, and cultural value, including 70 percent of the world’s #fisheries. The health of all the world’s #OceanEcosystems is in documented decline due
to a variety of stressors, including climate change, over-exploitation of resources, and pollution.

"The proposed release of this #contaminated water is a #transboundary and #transgenerational issue of concern for the health of marine ecosystems and those whose lives and livelihoods depend on them. We are concerned about the absence of critical data on the radionuclide content of each tank, the Advanced Liquid Processing System, which is used to remove radionuclides, and the assumption that upon the release of the contaminated wastewater,
‘dilution is the solution to pollution.’

“The underlying rationale of #dilution ignores the reality of biological processes of #OrganicBinding,
#bioaccumulation, and #bioconcentration, as well as accumulation in local seafloor sediments. Many of the radionuclides contained in the accumulated waste cooling water have half-lives ranging from decades to centuries, and their deleterious effects range from #DNADamage and
#cellular stress to elevated #cancer risks in people who eat affected marine organisms, such as clams, oysters, crabs, lobster, shrimp, and fish.

"Additionally, the effectiveness of the Advanced Liquid Processing System in almost completely removing the over 60 different #radionuclides present in the affected wastewater—some of which have an affinity to target specific tissues, glands, organs, and metabolic pathways in #LivingOrganisms, including people—remains a
serious concern due to the absence of critical data.

"The supporting data provided by the Tokyo Electric Power Company and the #JapaneseGovernment are insufficient and, in some cases, incorrect, with flaws in sampling protocols, statistical design, sample analyses, and assumptions, which in turn lead to flaws in the
conclusion of safety and prevent a more thorough evaluation of better alternative approaches to disposal. A full range of approaches to addressing the problem of safely containing, storing, and disposing of the radioactive waste have not been adequately explored, and alternatives to ocean dumping should be examined in greater detail and with extensive scientific rigor.

“NAML calls on the Government of #Japan and International Atomic Energy Agency (#IAEA) scientists to more fully and adequately consider the options recommended by the #PacificIslandsForum’s Expert Panel. We believe public policy decisions, regulations, and actions must keep pace with and make use of relevant advancements in our scientific understanding of the #environment and human health. In this case, we believe policy makers have not fully availed themselves of the available science and should do so before making any final decisions on releasing this contaminated water into the Pacific. NAML members are unified in our concern about use of the oceans as a dumping ground for radioactively contaminated water and other #pollutants because such actions can negatively affect the long-term health and sustainability of
our planet.

“We urge the Government of Japan to stop pursuing their planned and precedent-setting release of the radioactively contaminated water into the Pacific Ocean and to work with the broader scientific community to pursue other approaches [like #ClosedLoop systems or binding radionuclides in concerete] that protect #OceanLife; human health; and
those communities who depend on ecologically, economically, and culturally valuable marine
resources. “

Adopted by the NAML Board of Directors, December 12, 2022

https://www.naml.org/policy/documents/2022-12-12%20Position%20Paper,%20Release%20of%20Radioactively%20Contaminated%20Water%20into%20the%20Ocean.pdf

#WaterIsLife #OceansAreLife
#IAEAHides #TEPCOLies
#FukushimaIsntOver #NoDumping #NuclearPowerPlants #RadioactiveWater #RethinkNotRestart #PacificOcean #DataFalsification #ALPSSystem

Today Tim gave a quite vibrant presentation of the #biopixR package at our faculty at the #BTUCS. It was great to hear that some colleagues find it useful and want to use it for their research.

#bioimageinformatics #microbeads #microplastic #DNAdamage

How does the Wnt pathway promote resistance to #DNAdamage induced by #IonizingRadiation? @BenForWard3 &co show that #WntSignaling modulates DNA damage response via EGFR in #Drosophila, protecting cells from #apoptosis induced by DNA ds breaks #PLOSBiology https://plos.io/4dduEiq
Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway

The Wnt pathway promotes resistance to DNA damage induced by ionizing radiation in several human cancers, but the mechanisms are not fully understood. This study shows that Wnt signaling in the Drosophila wing imaginal disc modulates the DNA damage response through EGFR, protecting cells from apoptosis induced by DNA double-strand breaks.

ERC Advanced Grant for Helle Ulrich for research on DNA repair and genome stability