What if we could stop DNA repair errors before they happen — by moving the damage out of danger? #DNAdamage #CancerResearch #GenomeStability

https://geekoo.news/how-protein-droplets-shield-dna-from-catastrophic-errors/

How Protein Droplets Shield DNA From Catastrophic Errors | Geekoo

A newly discovered function of the Nup98 protein reveals how cells escort fragile DNA out of danger zones — offering clues for cancer therapy and anti-aging science.

Geekoo
Are #autophagy-related proteins involved in #GenomeStability? This study shows that Atg11 has an essential non-canonical function in error-free #chromosome segregation via the Kar9-dependent spindle positioning pathway @PLOSBiology https://plos.io/4lfbeP1
Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation

Autophagy-related proteins have roles in several cellular processes, but their function in genome stability remains unclear. Here, the authors show that Atg11 has an essential non-canonical function in error-free chromosome segregation via the Kar9-dependent spindle positioning pathway.

🔬 Call for abstracts – deadline is 18 March ✨

The EMBO | EMBL Symposium 'The ageing genome: from mechanisms to disease' is back with a fresh international speaker lineup! 🧬

#EESAgeing will bring together experts in chromosome biology, ageing sciences, and disease research.

Don't miss your chance to present! Submit your abstract here: https://s.embl.org/ees25-05-ma

#ageing #DNArepair #genomestability #emblevents #telomeres #DNAdamageresponse #ageinggenome #chromatinstability #epigenetics

The ageing genome: from mechanisms to disease

ERC Advanced Grant for Helle Ulrich for research on DNA repair and genome stability

ERC Advanced Grant for Helle Ulrich for research on DNA repair and genome stability

Discover Croatia's biomonitoring journey & compare across Europe with EDIAQI's latest findings. 🌍 Learn how factors like age, lifestyle, location, & weather affect genome damage from air pollutants. 🧬 EDIAQI sets baseline values for future research & policy development.

https://www.sciencedirect.com/science/article/abs/pii/S1383571824000251

#IAQ #EDIAQI #Biomonitoring #GenomeStability #HorizonEurope #Science

Goran Gajski

Cracking the functional domains of the RADX gene during replication. 🧬

Jessica Chevallier & Pierre Caron together highlight work from the #CortezLab which is now available online, ahead of print #JMolBiol.

Read the preLight! 👉https://prelights.biologists.com/highlights/crispr-dependent-base-editing-screens-identify-separation-of-function-mutants-of-radx-with-altered-rad51-regulatory-activity/

#CRISPR #GenomeStability #Replication #DSBs

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity - preLights

Cracking the functional domains of the RADX gene during replication

preLights

The PLK1 kinase mandates DNA polymerase theta to safeguard the #genome during #mitosis.

#preLighter Pierre Caron covers a #preprint by Camille Gelot #institut_curie and team that redefines the physiological function of #TMEJ.

#DNArepair #GenomeStability
https://prelights.biologists.com/highlights/pol%ce%b8-is-phosphorylated-by-polo-like-kinase-1-plk1-to-enable-repair-of-dna-double-strand-breaks-in-mitosis/

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis - preLights

The PLK1 kinase mandates DNA polymerase theta to safeguard the genome during mitosis.

preLights

https://igsad.de/9-phd-positions-available-in-the-research-unit-on-physiological-causes-and-consequences-of-genome-instability-1-230.html

🧬 ❌ 🧬 ❌
"Physiol. Consequences of Genome Instability"

Looking for your enthusiasm and your imagination!

📣 9 positions for PhD applicants are available within the novel research consortium FOR 5504.

Send us your application and join us in  !

Email to: schumacher-office[at]uni-koeln.de

Please re-toot! 🙏

#Science #PHDstudent #PhDposition #DNA #DNAdamage #Genome #GenomeStability
@UniKoeln
@CECAD
#KidneyResearch #Ciliopathies #Cilia #CellBiology

9 PhD positions available in the Research unit on Physiological causes and consequences of genome in

The new research unit FOR5504 has new PhD positions available on Physiological causes and consequences of genome instability....

Highly recommend #BiomedNews http://biomed.news/ as a tool for finding papers in your field (supplementing your Twitter/Mastodon feeds of course)

I've been maintaining a report on #NucleotideMetabolism and #GenomeStability in #cancer http://biomed.news/bims-numges Usually turns up some interesting papers I missed (report is currently a little out of date though 😬 - catching up is on the to do list...)