Chitosan-Based Hydrogels with N-Stearoylethanolamine for Acceleration of Healing of Acute Cutaneous Wounds: Cytological and Histological Examination - Cytology and Genetics

Abstract Wound management remains a significant clinical challenge, necessitating the development of advanced biomaterial solutions. This study aimed to evaluate the wound-healing potential of novel hydrogel films based on chitosan, hyaluronic acid, and the cannabimimetic N-stearoylethanolamine (NSE). Morphological studies of the surface of hydrogels were carried out using scanning electron microscopy, the biocompatibility and biodegradability of the created samples were evaluated in vitro in mouse BALB-3T3 fibroblast using the MTT test and staining with neutral red. Acceleration of healing of model excisional wounds of the skin of C57/Black laboratory mice was assessed histologically and by evaluating the rates of wound area reduction. The hydrogels used in the study showed high biocompatibility, increased the migration of fibroblasts to the cell-free zone (hydrogel sample without NSE), and induced lysosomal activity, which may indicate the bioavailability of the studied samples. Both hydrogels accelerated wound healing in mice, with faster epithelialization and remodeling of wound tissues observed in histological sections. The hydrogel sample with the cannabimimetic NSE showed its effect in the late stages of wound healing, while the gel without NSE showed activity in all phases of wound healing.

Scientists discover new type of cell in the liver

The newly-discovered cells help shed light on how the liver repairs itself after damage.

Scientists unveil a DIY structured-illumination microscope

For hundreds of years, the optical microscope was the only tool available to scientists wanting to study the movement of cells, bacteria and yeast. But the diffraction of light made it impossible to observe objects at resolutions of less than 100 nm because the resulting images were too blurry to be of any use.

Fatal Fats: Columbia Researchers Discover Rare Lipids Triggering Cell Death

Scientists have discovered that a rare lipid type plays a pivotal role in ferroptosis, a form of cell death. This finding sheds light on the mechanisms of cell death in ferroptosis and opens up possibilities for treating diseases by either preventing or inducing ferroptosis. Columbia researchers

Katayun Virkar - Wikipedia

ZS 2023 Vol. 62-42