0 likes, 0 comments - drhowardsmithreports on March 10, 2026: "Wound-healing Gel A new oxygen-delivering gel called BioGel helps prevent amputations in diabetics with otherwise non-healing wounds. It solves one of the biggest challenges in healing: lack of oxygen deep in tissue. Researchers at the University of California Riverside report in Communications Materials that a novel battery-powered gel that supports both local oxygen production and cell growth can continuously supply oxygen directly into slow-healing wounds. It dramatically improves healing in early tests. The BioGel system incorporates a bio-ionic liquid into gelatin methacryloyl that is conductive and biocompatible. Introducing a precise electric current with platinum or cobalt phosphate electrodes leads to oxygen generation by splitting water into oxygen and hydrogen. The preclinical study was conducted in high-risk diabetic and older mice, not human patients. In the untreated animals, wounds festered and were often fatal. But in the treatment group, where the oxygen gel was applied and replaced weekly, wounds healed in about 23 days and survival improved significantly. The contrast was stark: nonhealing, deteriorating wounds in controls versus consistent closure and recovery in treated animals. This gel delivers oxygen to the wound, speeds healing, and reduces the risk of amputation. However, this is still preclinical research, meaning human trials are needed before it becomes available for patients. Longer term, the same technology could even help in growing replacement tissues or organs. https://www.nature.com/articles/s43246-025-00947-4?error=server_error ‘https://www.sciencedaily.com/releases/2026/02/260222153000.htm ‘ #diabetes #woundhealing #gel #electricity".
A longitudinal profiling of #microbiome of diabetic foot ulcers shows functional role of microbial communities in wound worsening and chronicity
https://www.sciencedirect.com/science/article/pii/S2666517425002044 #OpenAccess #diabetes #microbiota #MicroSky #IDSky #WoundHealing
Abstract Wound management remains a significant clinical challenge, necessitating the development of advanced biomaterial solutions. This study aimed to evaluate the wound-healing potential of novel hydrogel films based on chitosan, hyaluronic acid, and the cannabimimetic N-stearoylethanolamine (NSE). Morphological studies of the surface of hydrogels were carried out using scanning electron microscopy, the biocompatibility and biodegradability of the created samples were evaluated in vitro in mouse BALB-3T3 fibroblast using the MTT test and staining with neutral red. Acceleration of healing of model excisional wounds of the skin of C57/Black laboratory mice was assessed histologically and by evaluating the rates of wound area reduction. The hydrogels used in the study showed high biocompatibility, increased the migration of fibroblasts to the cell-free zone (hydrogel sample without NSE), and induced lysosomal activity, which may indicate the bioavailability of the studied samples. Both hydrogels accelerated wound healing in mice, with faster epithelialization and remodeling of wound tissues observed in histological sections. The hydrogel sample with the cannabimimetic NSE showed its effect in the late stages of wound healing, while the gel without NSE showed activity in all phases of wound healing.
<p>Fully open-access journal publishing the latest basic, clinical and translational research and reviews in the field of vascular biology, including cardiology, oncology, vascular development, inflammation, wound healing, and bioengineering. (published by Bioscientifica)</p>
Longevity Based
Howard Smith MD, AM
All Scientifical
David Ojcius
valentinzi
Cytology and Genetics
ScienceOpen