'we did not attempt to identify the HuFl microbial mimic, as identifying it would lack translational relevance.'
then demonstrating that #Akkermansia contributes to #autoimmunity also offers little translational value. What exactly would you do?
https://www.biorxiv.org/content/10.64898/2025.12.04.691931v1
Pretty remarkable finding. The only question is, why isn’t everyone bald, given how common stress is?
Duchenne muscular dystrophy might have an autoimmune side after all. In mice, CD4⁺ T cells cause heart damage and removing them keeps the heart healthy. Big implications for future DMD treatments.
Duchenne muscular dystrophy (DMD) is a X-linked genetic disorder, in which cardiomyopathy represents a major cause of mortality. Although myocardial inflammation and fibrosis are hallmarks of the disease, the role of adaptive immunity in cardiac pathology remains poorly defined. Using the Mdx mouse model, we demonstrate that T and B lymphocytes accumulate in the heart and that activation occurs in heart-draining lymph nodes at an early disease stage. Mdx mice lacking adaptive immunity (Mdx-Scid) were protected from myocardial fibrosis and hypertrophic remodeling. Single-cell RNA sequencing revealed expansion of an inflammatory, matrisome-associated macrophage subset in Mdx but not Mdx-Scid hearts. Genetic deficiency or depletion of CD4⁺ T cells reduced left ventricular fibrosis and preserved systolic function. Moreover, adoptive transfer of T cells von Mdx mice induced myocardial fibrosis and dysfunction in healthy recipients. Our results identify autoreactive CD4⁺ T cells as key drivers of DMD-associated cardiomyopathy and suggest targeted modulation of adaptive immune responses as a potential therapeutic approach in DMD. ### Competing Interest Statement The authors have declared no competing interest. Deutsche Forschungsgemeinschaft, 453989101, 449933847 German Heart Research Foundation, https://ror.org/02yjb3a91, F/02/16
Research Assistant in Systems Immunology & Cell Design
University of Pennsylvania
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/
#Autoimmunity #bioengineering #cancerimmunology #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/?fsp_sid=3693
Discovery of C9orf72 as a Target of Autoimmune T Cell Responses in ALS
A new study published in *Nature* identifies C9orf72 as the first confirmed target of autoimmune T cell responses in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive motor neuron loss and a mean survival of around four years after diagnosis. ALS is associ... [More info]
Research Assistant in Systems Immunology & Cell Design
University of Pennsylvania
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/
#Autoimmunity #bioengineering #cancerimmunology #molecularbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-pennsylvania-27778-research-assistant-in-systems-immunology-cell-design/?fsp_sid=3287
🎥 #Documentary #ChronicallyIgnored
Only a few days left until June 20th. I would be very grateful for sharing, so that as many people as possible can be reached! Thank you so much for your support!
A Wake-Up Call To Politics, Medicine & Research
#POTS #SmallFiber #SIBO #Autoimmunity #MCAS #FQAD #FQToxicity #FlagylToxicity #EDS #hEDS #Marfan #CCI #LongCovid #LongLyme #VacInjury #LongList #LongTragedy
Film Link here:
🎥https://vimeo.com/ondemand/chronicallyignored
Ok, so remember the whole "COVID-19 seems to have superantigenic properties but it's not clear which of its proteins drive that" thing?
Persistent N protein in peripheral blood might be one driver of autoimmunity: https://disabled.social/@tomkindlon/114673383700458817
Attached: 1 image US research: "our findings suggest that the persistence of #SARSCoV2 N-protein in peripheral blood promotes a chronic inflammatory milieu, even several months after active infection..." https://www.biorxiv.org/content/10.1101/2025.06.02.657400v1 Image from Science for ME update @longcovid@a.gup.pe #LongCovid #PASC #PwLC #postcovid #postcovid19 #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC @covid19@a.gup.pe #Coronavirus #COVID19 #COVID #COVID_19 #COVIDー19 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver @auscovid19@a.gup.pe #auscovid19
Unravel the mystery: Explore how hormones, genetics, and environment contribute to the higher prevalence of autoimmune diseases in women. Discover the latest insights here!
https://mrmed-6851.freshlearn.com/blog/3338
#AutoimmuneDiseases #WomenHealth #Autoimmunity #GenderDisparity #ImmuneSystem
David Usharauli
Sparwasser Lab
jobRxiv
qukahnata at KillBait
Sibylle Dahrendorf
datum (n=1)
MrMed : Online Pharmacy