🧪 Daily Lab Note
Why Your Muscles Grow After the Workout, Not During It
New Science Reveals the Hidden Energy Switch That Controls Muscle Growth
· Resistance exercise activates AMPK, temporarily suppressing muscle protein synthesis
· AMPK shifts role post-workout, triggering a powerful anabolic rebound 1–2 hours later
· Muscle growth is a recovery process — not a result of exertion
“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee #ISOGG #geneadons #caffeine #AMPK #MTOR
Another paper about AMPK. This gives a good overview as well as information about AMPK activation.
Takeaway: If you wish you had access to Metformin but don't, you might want to look into what this paper says about AMPK activation.
AMP-activated kinase (AMPK) is activated when the cellular (AMP+ADP)/ATP ratio rises; it therefore serves as a detector of cellular “fuel deficiency.” AMPK activation is suspected to mediate some of the health-protective effects of long-term calorie ...
A new study from the Cellular Aging and Senescence laboratory at Queen Mary University of London's Centre for Molecular Cell Biology reveals how caffeine—the world's most popular neuroactive compound—might do more than just wake you up.
SciTech Chronicles. . . . . . . . . . . . . . . . . Jan 16, 2025
#Antiaging #longevity #LCA #bile #AMPK #liver #AMOC #WHOI #climate #fluxes #proxy-based #British #DNA #Durotriges #Dorset #U5b1 #mitochondrial #Alzheimer’s #Parkinson’s #amyloid #Tau #dopamine #Iceland #Bárðarbunga #eqrthquake #swarm #Holuhraun
Why eating less slows ageing: Lithocholic acid
https://www.nature.com/articles/d41586-024-04220-5
non-paywalled https://archive.fo/J3dHo
https://news.ycombinator.com/item?id=42478962
Lithocholic acid binds TULP3 to activate sirtuins/AMPK to slow ageing
https://www.nature.com/articles/s41586-024-08348-2
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
https://www.nature.com/articles/s41586-024-08329-5
Lithocholic acid: https://en.wikipedia.org/wiki/Lithocholic_acid
* bile acid; solubilizes fats for absorption
#LithocholicAcid #ageing #aging #CalorieRestriction #sirtuins #AMPK #MolecularBiology
Practice intermittent fasting: Intermittent fasting has been shown to increase AMPK activity and improve glucose and lipid metabolism.
Read more 👉 https://lttr.ai/ATHz7
#Ampk #HormoneImbalance #HowToActivateAmpk #Wellness #BrownAdiposeTissue
Regulating glucose metabolism: AMPK stimulates glucose uptake and breakdown in skeletal muscle and other tissues while inhibiting glucose production in the liver.
Read more 👉 https://lttr.ai/APKpl
#Ampk #HormoneImbalance #HowToActivateAmpk #Wellness #BrownAdiposeTissue
FitBodyScience
ISOGG
Shaula Evans
Benjamin Carr, Ph.D. 👨🏻💻🧬
Fabrizio Benedetti
John Vaccaro (johniac)
Victoria Stuart 🇨🇦 🏳️⚧️
Rhyothemis
PamelaTorontoNaturopath