“The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) that enables cells to maintain their proper balance of
#NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels.”
#ISOGG #DNA #geneadons https://case.edu/news/new-study-shows-alzheimers-disease-can-be-reversed-achieve-full-neurological-recovery-not-just-prevented-or-slowed-animal-models
New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models | CWRU Newsroom | Case Western Reserve University
For more than a century, people have considered Alzheimer's disease (AD) an irreversible illness. Consequently, research has focused on preventing or ...
“By using state-of-the-art DNA techniques and newly published genomes, we were able to determine the ancestry of the Beachy Head Woman with much greater precision than before,” William reveals.”
#ISOGG #DNA #AncientDNA #BeachyHeadWoman #UK #geneadons https://www.nhm.ac.uk/discover/news/2025/december/the-changing-story-beachy-head-woman.html
The changing story of the Beachy Head Woman | Natural History Museum
The identity of a mysterious Roman-era skeleton found in southern England may have finally been resolved.
“If these efforts manage to pinpoint Leonardo’s Y chromosome, its sequence would become the project’s genomic ground truth. DNA recovered from other sources—such as works of art—could be measured against it, providing a powerful tool for authentication. It might also unlock genetic clues to Leonardo’s genius.”
#leonardodavinci #DNA #ISOGG https://www.science.org/content/article/have-scientists-found-leonardo-da-vinci-s-dnaIGG FREE KINDLE BOOK!
#igg is the acronym for “Investigative Genetic Genealogy” and this book is addictive; I already own it so highly recommend it! Use this link to get the book free on Kindle and if you don’t have a Kindle, you can read it using the Audible smartphone app. Thanks for the heads up on the free book, Thomas MacEntee
https://genealogybargains.com/amazon-chester-creek-murders #TrueCrimeAddict #DNA #ISOGG #ArmchairDetective #FreeReads #Mystery #BookAddict #KindleHigher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD. Our study's observational design limits causal inference”
#ISOGG #DNA #epigenetics #dementia #geneadons #alzheimers #cheese #brie #cheddar #cognitivedecline https://www.neurology.org/doi/10.1212/WNL.0000000000214343“We discovered 3 regions of the genome carrying distinct DNA methylation profiles in sperm from individuals with history of childhood psychological stress, notably at proximity of genes regulating the development of the central nervous system.”
#ISOGG #DNA #epigenetics https://www.nature.com/articles/s41380-024-02872-3
Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm - Molecular Psychiatry
Childhood maltreatment exposure (CME) increases the risk of adverse long-term health consequences for the exposed individual. Animal studies suggest that CME may also influence the health and behaviour in the next generation offspring through CME-driven epigenetic changes in the germ line. Here we investigated the associated between early life stress on the epigenome of sperm in humans with history of CME. We measured paternal CME using the Trauma and Distress Scale (TADS) questionnaire and mapped sperm-borne sncRNAs expression by small RNA sequencing (small RNA-seq) and DNA methylation (DNAme) in spermatozoa by reduced-representation bisulfite sequencing (RRBS-seq) in males from the FinnBrain Birth Cohort Study. The study design was a (nested) case-control study, high-TADS (TADS ≥ 39, n = 25 for DNAme and n = 14 for small RNA-seq) and low-TADS (TADS ≤ 10, n = 30 for DNAme and n = 16 for small RNA-seq). We identified 3 genomic regions with differential methylation between low and high-TADS and 68 tRNA-derived small RNAs (tsRNAs) and miRNAs with different levels in males with high CME (False discovery rate, FDR corrected p < 0.05). Of potential interest, we identified differential expression of miRNA hsa-mir-34c-5p and differential methylation levels near the CRTC1 and GBX2 genes, which are documented to control brain development. Our results provide further evidence that early life stress influences the paternal germline epigenome and supports a possible effect in modulating the development of the central nervous system of the next generation.
“Our finding multiple high‐level and sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves that although a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.”
#DNA #Haplogroup #HaplogroupL #isogg #mitochrondria #PMD #mtDNA https://pmc.ncbi.nlm.nih.gov/articles/PMC12254466/
Mitochondrial DNA Pathogenic Variant Prevalence in Primary Mitochondrial Disease Patients With African (L) Mitochondrial Genome Haplogroups
Primary mitochondrial diseases (PMD) are caused by pathogenic variants in over 350 genes, 37 of which are located in mitochondrial DNA (mtDNA). While more than 100 mtDNA variants have confirmed disease associations, there are few reports of ...
Just finished watching the fascinating documentary “Secrets of the Neanderthals” on Netflix. Not a lot of DNA discussion but there is one part where they can identify whether the remains are male or female based on a dental protein.
#DNA #ISOGG #neanderthals #Netflix #ShanidarZ #geneadons Here’s a link to the trailer:
https://youtu.be/b5YtgLSU_sE?si=Ua4xg54r3hnrEdgQ
Secrets of the Neanderthals | Official Trailer | Netflix
“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," the authors of the study conclude.
#DNA #ISOGG #mounjaro #zepbound #diabetes #tirzepetide #epigeneticshttps://www.nature.com/articles/s41591-025-04035-5
Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide - Nature Medicine
This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.
ISOGG
Katherine Borges