ISOGGAug 12
Well done study on the HAY surname! #ISOGG #DNA #FTDNA #FamilyTreeDNA #geneadons #Hay #geneticgenealogy https://www.biorxiv.org/content/10.1101/2025.07.09.664039v4.full
ISOGGAug 5

“…scientists made a surprising discovery: caffeine doesn’t act on this growth switch directly. Instead, it works by activating another important system called AMPK, a cellular fuel gauge that is evolutionarily conserved in yeast and humans.” #DNA #epigenetics #coffee #ISOGG #geneadons #caffeine #AMPK #MTOR

https://www.qmul.ac.uk/media/news/2025/science-and-engineering/se/caffeine-could-slow-cellular-ageing-new-research-shows-how.html

Caffeine could slow cellular ageing, new research shows how

Queen Mary University of London
ISOGGAug 1
Have you had the Shingles vaccine? If you’ve had the Shingles vaccine (and/or RSV vax) then you may have given yourself a dementia preventative. #isogg #dna #shingles #shingrix #RSV #epigenetics #geneadons #vaccine https://www.sciencealert.com/huge-study-reveals-2-vaccines-that-appear-to-reduce-dementia-risk
Huge Study Reveals 2 Vaccines That Appear to Reduce Dementia Risk

Some immunizations may be quietly protecting us from cognitive decline.

ScienceAlert
ISOGGJul 31

“Intranasal insulin has been clinically tested in AD patients, demonstrating positive effects on memory and a decrease in Aβ42 levels. Future studies may then reveal the further potential for these novel constructs to deliver drugs that halt or reverse Aβ42 aggregation to the hippocampal neurons; simply by nasal administration.” #DNA #epigenetics #isogg #Alzheimers #insulin #geneadons

https://pmc.ncbi.nlm.nih.gov/articles/PMC11626187/

Insulin-inspired peptides may open new pathways to treat Alzheimer’s disease

PubMed Central (PMC)
ISOGGJul 29
“Over an average follow-up of 6.7 years, 280 participants, or 27.3 percent, were diagnosed with Alzheimer’s dementia. Researchers found that 39 percent of the “total effect of egg intake” was linked to choline, a nutrient found in egg yolks known to support memory and brain function.” #isogg #DNA #epigenetics #choline #Alzheimers #dementia https://thehill.com/policy/healthcare/5414072-eating-eggs-lowers-risk-alzheimers-study/amp/
Eating eggs weekly may lower Alzheimer’s risk by nearly 50 percent: Study

About 39% of egg benefits came from choline intake, researchers found.

The Hill
ISOGGJul 11

“When IDO1 is blocked, however, macrophages regain their ability to absorb cholesterol.This suggests that reducing IDO1 activity could offer a new way to help prevent heart disease by keeping cholesterol levels in check.” #DNA #isogg #epigenetics #cholesterol #geneadons

https://www.news-medical.net/news/20250627/New-enzyme-can-be-turned-off-to-restore-cholesterol-balance-and-reduce-inflammation.aspx

New enzyme can be "turned off" to restore cholesterol balance and reduce inflammation

Scientists at The University of Texas at Arlington have identified a new enzyme that can be "turned off" to help the body maintain healthy cholesterol levels-a significant development that could lead to new treatments for diseases that affect millions of Americans.

News-Medical
ISOGGJul 9

“These findings identify a light-responsive cell-intrinsic timer that controls time-of-day variations in antibacterial activity.” #isogg #DNA #epigenetics #circadian #geneadons

https://www.science.org/doi/10.1126/sciimmunol.adn3080

ISOGGJul 6
“Addressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.”
#isogg #epigenetics #geneadons #dementia #alzheimers https://pubmed.ncbi.nlm.nih.gov/33570509/
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States - PubMed

Addressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.

PubMed
ISOGGJul 4
“Their study, published in the journal Nature, describes the first whole ancient Egyptian genome, and the oldest DNA sample from Egypt to date.” #DNA #isogg #Egypt #Nature https://amp.dw.com/en/dna-shows-ancient-egyptians-had-surprising-foreign-roots/a-73114279
DNA shows ancient Egyptians had surprising foreign roots

Scientists have sequenced the oldest known DNA from ancient Egypt. It belonged to a potter who lived 4,500 years ago. This rare genetic snapshot offers new insights into the diverse ancestry of early Egyptians.

Deutsche Welle
ISOGGJun 29

“This innovative strategy could potentially revolutionize our ability to address genetic hearing impairments, offering hope for more effective and durable treatments for individuals across a wider age range and at various stages of hearing loss progression.” #isogg #DNA #epigenetics #hearingloss #geneadons

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1511938/full

Frontiers | Gene therapy for hearing loss: challenges and the promise of cellular plasticity and epigenetic modulation

Hearing loss can profoundly impact an individual’s quality of life, affecting communication, social interactions, and overall well-being. Many people with he...

Frontiers