As human cells age, the packaged form of DNA within the cell nucleus, known as chromatin, undergoes structural degradation and physically opens up. This alteration causes older cells to respond weakly or incorrectly to external mechanical and biochemical stimuli, leading to impaired cellular function.
#MolecularBiology #CellBiology #Mechanobiology #Biogerontology #sflorg
https://www.sflorg.com/2026/03/mbio03262601.html
Why cells respond “incorrectly” in old age

Some of the signs of ageing in human cells originate in the cell nucleus, because the packaged form of DNA changes with age.

"We live in an academic culture increasingly defined by metrics that attempt to quantify academic worth but inevitably fail to capture its full substance. Measures such as the H-index cannot account for the intangible yet profound contributions scientists make to the intellectual lives and careers of one another. Catherine cared deeply about people and invested enormous energy in sharpening their thinking and the clarity of the way they expressed their ideas. She did so not quietly or passively, but through direct and often challenging discussions that pushed their science to become clearer, stronger, and more honest. While her research alone has left an indelible mark on our understanding of secretion pathways and organelle dynamics, it is an irony Catherine herself would have appreciated—given her lifelong fascination with numbers—that perhaps her most enduring influence lies in contributions that resist quantification, carried forward in the work, confidence, and clarity of thought of those she trained, challenged, and inspired."

From: "In memoriam: Catherine Rabouille".

https://rupress.org/jcb/article/225/4/e202508130/281671/In-memoriam-Catherine-Rabouille-1962-2025-In

#CellBiology #RIP #academia

In memoriam: Catherine Rabouille (1962–2025)

The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with i

Rockefeller University Press
Rapaza viridis, a single-celled predator, performs #photosynthesis by stealing and temporarily retaining chloroplasts from its algal prey, a process known as kleptoplasty. It actively maintains these stolen organelles by transporting its own host-encoded proteins into them.
#EvolutionaryBiology #CellBiology #MolecularBiology #AgriculturalScience #sflorg
https://www.sflorg.com/2026/03/ebio03252601.html
Stolen chloroplasts maintained by host-made proteins offer clues to plant cell origins

The single-celled predator Rapaza viridis temporarily retains chloroplasts from prey algae and imports its own proteins into them

High-pressure freezing is a novel #cryopreservation technique that utilizes extreme pressure and rapid cooling to instantaneously freeze biological samples into a noncrystalline solid state via vitrification.
#Cryobiology #Bioengineering #CellBiology #RegenerativeMedicine #sflorg
https://www.sflorg.com/2026/03/beng03252601.html
Successful use of high-pressure freezing for cell cryopreservation

A high-pressure method of instantaneously freezing cells proves to be effective in the first empirical validation of its kind.

🔧 Flexibly assembled: Proteasomes, the cells’ garbage cans, are assembled in different ways
A new study by University Potsdam and the #UniCologne shows that the assembly of the proteasome, a central component of cellular protein quality control, does not follow a rigid program but uses flexible pathways. This discovery challenges established views in research.

Read more▶️ https://uni-koeln.de/en/university/news/news/news-detail/flexibel-montiert-alternative-wege-in-der-proteasom-biogenese-entschluesselt

📰 https://www.nature.com/articles/s41467-026-70525-w

#uniköln #unicologne #Proteasome #ProteinResearch #CellBiology

Researchers have discovered that the protein CD47 plays a direct, internal role in driving the growth, movement, and invasion of glioblastoma cells into healthy brain tissue, operating independently of its previously established function in immune evasion.
#Oncology #CellBiology #Neuroscience #sflorg
https://www.sflorg.com/2026/03/ongy03242601.html
New discovery reveals hidden driver of deadly brain cancer

Glioblastoma is extremely difficult to treat, with most patients surviving less than 18 months after diagnosis.

RE: https://fediscience.org/@PLOSBiology/116283668972869123

I’m channeling @CellySally to declare the #PaperThemeTune for this paper (and highlight) is “Accidents Will Happen" by Elvis Costello.

It suggests that alternative splicing (+ other) events are just accidents on the way to making the real protein's transcript.
#CellBiology

Today's talk will be:

Isaac Wong (Dunn School, Oxford)

Mechanical Principles of Centrosome Assembly and Function

CTU 0.08/09 at 13.05

#CellBiology #cytoskeleton

Egg cells made with DNA from human skin fertilised in the lab

An innovative use of skin cells could provide a route for gay couples or women with fertility problems to have children they are both genetically related to

Pure Science News
Egg cells made with DNA from human skin fertilised in the lab

An innovative use of skin cells could provide a route for gay couples or women with fertility problems to have children they are both genetically related to

Pure Science News