Mastodawn

ST8Sia5L is a brain enzyme that regulates its own activity by synthesizing a polysialic acid chain directly onto its own molecular structure, triggering its deactivation and subsequent secretion from the cell.
#MolecularBiology #Glycobiology #Neuroscience #CellBiology #sflorg
https://www.sflorg.com/2026/06/mbio06182601.html

ST8Sia5L Enzyme: A Novel Autopolysialylation Discovery

Discover how the ST8Sia5L brain enzyme uses autopolysialylation to self-regulate, overturning decades of assumptions about cellular glycosylation.

Scientific Frontline 4d ago

AD-NP1 is a monoclonal antibody drug developed to promote the repair and regeneration of damaged internal organs by inhibiting a protein that naturally obstructs tissue healing.
#RegenerativeMedicine #MolecularBiology #CellBiology #Nephrology #Pharmacology #sflorg
https://www.sflorg.com/2026/06/med06162601.html

UCLA Drug AD-NP1 Regenerates Kidney Tissue

UCLA scientists discovered that AD-NP1, an antibody designed for heart repair, inhibits the ENPP1 protein to successfully regenerate kidney tissue.

Scientific Frontline 4d ago

Bacillus subtilis regulates its cell duplication via a self-organizing mechanism where the MinD protein dictates spatial patterning through an intrinsic, membrane-bound ATP-dependent cycle. This demonstrates that the bacterium achieves precise cellular division without the need for a specific activator protein.
#Biochemistry #CellBiology #Microbiology #Biophysics #sflorg
https://www.sflorg.com/2026/06/bchm06162601.html

Cell Division Regulation in Bacillus subtilis

Discover how B. subtilis regulates cell division without MinE. Membrane-bound MinD proteins drive this self-organizing biological process.

Magnus Idode Jun 12

Life begins with cells.

From the microscopic union of a single human egg and sperm, a complex network of 10 trillion cells is built to create a human life. Molecular cell biology teaches us that whether an organism is a tiny single cell or a complex human being, the fundamental building blocks of life are remarkably connected.

#Science #CellBiology #NatureOfLife #Discovery

pub2post Jun 11

Golgi vesicles aid mitochondrial fission.
🧩 Golgi-derived vesicles modulate fission.
🧬 Arf1 and PI(4)KIIIb drive mitochondrial fission.
🧪 PI(4)P crucial for mitochondrial division.

#MitochondrialFission #CellBiology https://tnyp.me/m8aIDIpw/m

Hacker News Jun 8

Why are cells small?

https://burrito.bio/essays/what-limits-a-cells-size

#HackerNews #cellbiology #cellsize #scienceeducation #microbiology #research

Why Are Cells Small?

Two physical constraints — surface area and diffusion — explain why cells are (usually) tiny.

mechanochemistry Jun 7

New paper from Catriona Conway and colleagues in the McAinsh/Burroughs group.

Single kinetochores execute an ordered series of molecular events as the spindle assembly checkpoint is silenced

https://doi.org/10.1016/j.celrep.2026.117493

#CellBiology #Microscopy #TeamQuantification

Scientific Frontline Jun 7

Exosomes are highly specific, nanoscale extracellular vesicles (30 to 150 nm in diameter) that function as a biological "molecular internet," transporting targeted payloads of proteins, lipids, and nucleic acids (such as mRNA and miRNA) to facilitate complex, systemic intercellular communication.
#WhatIs #Bioinformatics #CellBiology #MolecularBiology #Oncology #Pharmacology #sflorg
https://www.sflorg.com/2026/06/wi06072601.html

What Is: Extracellular Vesicles (Exosomes)

Discover how exosomes act as the body's molecular internet, revolutionizing cellular biology, targeted drug delivery, and liquid biopsy diagnostics.

Scientific Frontline Jun 4

Astrocytes, the star-shaped glial cells in the brain, actively shuttle lactate to neurons not only as an energy source but as a critical signaling molecule that modulates cellular chemistry and cements learning and memory.
#Neuroscience #Neurobiology #Neurochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/06/ns06042602.html

Astrocytic Lactate: The Hidden Driver of Brain Memory

Astrocytes shuttle lactate to neurons, acting as a signaling molecule that amplifies NMDA receptors to strengthen synapses and cement memory.

Scientific Frontline Jun 3

A newly defined modular framework organizing over 8,000 individual neurons in the Drosophila cerebrum into fewer than 200 fundamental structural groups, simplifying the link between molecular programming and behavior.
#Neurobiology #MolecularBiology #CellBiology #Genetics #DevelopmentalBiology #sflorg
https://www.sflorg.com/2026/06/ns06032601.html

Neuron Ground Plans: Simplifying Brain Research

Discover how organizing neurons into 200 structural ground plans simplifies complex neurobiology research, linking specific genes to behaviors.