Mastodawn

🔬🧪 Ah, the groundbreaking #discovery of how cells throw a temper tantrum! But wait, before you get to the part where science saves the world, you need to enable cookies, because apparently, even cellular biology requires a sweet tooth and a #JavaScript diploma these days. 🍪📜
https://news.stanford.edu/stories/2026/03/immune-response-inside-cells-inflammation-research #cellbiology #sciencecookies #tempertantrum #HackerNews #ngated

Scientists capture how cells trigger inflammation

SLAC scientists observed an immune signaling complex forming inside cells for the first time, revealing insights that could guide new treatments.

matecurkovic 3d ago

Scientists have discovered hidden “winds” inside cells that actively push proteins forward, speeding up movement and repair. These cellular currents challenge decades of textbook biology and may explain why some cancer cells spread so rapidly. This breakthrough could open new doors for cancer research and therapy. #CellBiology #CancerResearch #ScientificDiscovery

Scientific Frontline 4d ago

A chemical compound, an analog of G2, that prevents neuronal death by enhancing autophagy to clear harmful, misfolded tau proteins from brain cells.
#Neuroscience #CellBiology #Neuropharmacology #MolecularGenetics #sflorg
https://www.sflorg.com/2026/04/ns04012601.html

Chemical compound clears cellular waste, protects neurons in model of frontotemporal dementia

Restoring autophagy is promising strategy for range of neurodegenerative diseases

Scientific Frontline 5d ago

Cell Painting is a scalable, image-based cellular profiling method that utilizes fluorescent dyes and artificial intelligence to measure thousands of molecular and structural changes in human cells following chemical exposure.
#Toxicology #Pharmacology #CellBiology #ComputationalBiology #sflorg
https://www.sflorg.com/2026/03/phar03312601.html

Scalable cell imaging method could help make drug safety testing faster, cheaper

Researchers show that Cell Painting, an image-based cell profiling method, can reveal details of how drug candidates and other chemicals may harm cell

Scientific Frontline 6d ago

Before a cell can divide, its #genetic material—tightly packed into a DNA-protein complex known as chromatin—must be temporarily reorganized. This structural modification exposes specific starting points along the DNA, ensuring the cellular machinery can precisely duplicate the genetic information.
#MolecularBiology #Biochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/03/mbio03312601.html

Precision work prior to cell division: how enzymes optimize DNA structure

Understanding of these regulatory mechanisms offers potential therapeutic pathways for diseases characterized by unregulated cell division, such as ca

Scientific Frontline 6d ago

Cells utilize actively directed, targeted streams of fluid—comparable to internal "trade winds" or atmospheric rivers—to rapidly transport essential soluble proteins to their leading edge to facilitate movement, adhesion, and repair.
#CellBiology #Biophysics #BiomedicalEngineering #Oncology #sflorg
https://www.sflorg.com/2026/03/cbio03302601.html

OHSU study uncovers internal cell ‘trade winds’ that drive movement and repair

Breakthrough research reveals that cells use directed fluid flows to push key proteins forward

Scientific Frontline Mar 30

The natural supercoiling and physical twisting of DNA inside cells increase its susceptibility to unintentional, off-target cutting by the CRISPR-Cas9 gene-editing system.
#MolecularBiology #Genetics #CellBiology #Bioengineering #sflorg
https://www.sflorg.com/2026/03/mbio03302601.html

DNA shape explains crucial gene-therapy challenges

A mystery surrounding why powerful gene-editing technology that has driven major advances

jobRxiv Mar 29

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=10761

NTT Research Assistant Professor or Postdoctoral Scholar

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

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Scientific Frontline Mar 26

As human cells age, the packaged form of DNA within the cell nucleus, known as chromatin, undergoes structural degradation and physically opens up. This alteration causes older cells to respond weakly or incorrectly to external mechanical and biochemical stimuli, leading to impaired cellular function.
#MolecularBiology #CellBiology #Mechanobiology #Biogerontology #sflorg
https://www.sflorg.com/2026/03/mbio03262601.html

Why cells respond “incorrectly” in old age

Some of the signs of ageing in human cells originate in the cell nucleus, because the packaged form of DNA changes with age.

Albert Cardona Mar 26

"We live in an academic culture increasingly defined by metrics that attempt to quantify academic worth but inevitably fail to capture its full substance. Measures such as the H-index cannot account for the intangible yet profound contributions scientists make to the intellectual lives and careers of one another. Catherine cared deeply about people and invested enormous energy in sharpening their thinking and the clarity of the way they expressed their ideas. She did so not quietly or passively, but through direct and often challenging discussions that pushed their science to become clearer, stronger, and more honest. While her research alone has left an indelible mark on our understanding of secretion pathways and organelle dynamics, it is an irony Catherine herself would have appreciated—given her lifelong fascination with numbers—that perhaps her most enduring influence lies in contributions that resist quantification, carried forward in the work, confidence, and clarity of thought of those she trained, challenged, and inspired."

From: "In memoriam: Catherine Rabouille".

https://rupress.org/jcb/article/225/4/e202508130/281671/In-memoriam-Catherine-Rabouille-1962-2025-In

#CellBiology #RIP #academia

In memoriam: Catherine Rabouille (1962–2025)

The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with i

Rockefeller University Press