As a medical school professor, I spent years teaching that Alzheimer's is an amyloid disease. A comprehensive new review in the Journal of Clinical Medicine confirms what I now believe: Alzheimer's is a metabolic disease.

Key findings from the evidence synthesis:

-> Glucose hypometabolism appears BEFORE amyloid plaques form
-> Insulin resistance accelerates cognitive decline and tau pathol... https://pmc.ncbi.nlm.nih.gov/articles/PMC12986246/

#Alzheimers #MetabolicHealth #InsulinResistance #BrainHealth #HealthLongevity

1 in 3 American Teens Now Prediabetic

I teach medical students about diabetes every year. But this number stopped me cold.

1 in 3 American teenagers is now prediabetic.

CDC/NHANES data confirms 32.7% of 12-17 year olds -- an estimated 8.4 million kids -- have blood sugar in the prediabetes range. Up from 9% just two decades ago.

The strongest predictor? Not diet. Not exercise. Waist-to-... https://www.statnews.com/2025/07/09/prediabetes-in-teens-cdc-says-nearly-one-in-three-teenagers-at-risk-of-type-2-diabetes/

#Prediabetes #MetabolicHealth #ChildHealth #InsulinResistance #HealthLongevity

Smartwatch Predicts Insulin Resistance

Your smartwatch may know you're becoming diabetic before your doctor does.

As a medical school professor, I've spent decades relying on fasting glucose and HbA1c to screen patients. But a landmark Nature study just proved those tests miss millions.

Researchers built an AI model using data from 1,165 people -- combining smartwatch signals (resting hea... https://www.nature.com/articles/s41586-026-10179-2

#InsulinResistance #MetabolicHealth #Wearables #DiabetesPrevention #Longevity

Antibiotics & Gut Microbiome

As a medical school professor, I taught that antibiotics are targeted weapons. New research says I was wrong about how "targeted" they really are.

A study of 14,979 adults in Nature Medicine found that a SINGLE course of antibiotics can reshape your gut microbiome for 4 to 8 YEARS.

The Uppsala University team linked drug registries to microbiome mapp... https://www.uu.se/en/press/press-releases/2026/2026-03-11-antibiotics-can-affect-the-gut-microbiome-for-several-years

#GutMicrobiome #Antibiotics #MetabolicHealth #InsulinResistance #HealthLongevitySecrets

As a medical school professor, I teach that inflammation from excess visceral fat drives insulin resistance. But a new Pitt study reveals something I never expected:

Your fat tissue contains "good" immune cells that SUPPRESS that inflammation.

They're called resident macrophages, and a protein called SerpinB2 keeps them alive. But when visceral fat builds up, SerpinB2 plummets, these cells die off,... https://www.medschool.pitt.edu/news/pitt-research-reveals-protective-key-may-curb-insulin-resistance-and-prevent-diabetes

#InsulinResistance #Diabetes #MetabolicHealth #Immunology #Longevity

As a medical school professor, I've taught for years that insulin resistance drives diabetes. But a massive new study proves it drives cancer too.

Researchers built an AI tool to predict insulin resistance using 9 routine blood markers -- and tested it on 372,000 UK Biobank participants.

Result: insulin resistance raised cancer risk by 25% across 12 types.

The worst hit: uterine cancer (+134%), ki... https://www.nature.com/articles/s41467-026-68355-x

#InsulinResistance #CancerPrevention #MetabolicHealth #Longevity #AI