Mastodawn

Our new paper published in the Computational and Structural Biotechnology Journal explains how ligands binding the exact same IL1R1 site produce opposite outcomes.

We used MD simulations and CABS-flex to show how IL1 receptor antagonists block signaling despite binding the exact same site as agonists. Instead of a static blockade, antagonists actively disrupt distal D3 domain dynamics.

Read here: https://doi.org/10.34133/csbj.0017

#MolecularDynamics #Biophysics #StructuralBiology #Allostery

CSBJ 12h ago

🧱 What if activation and inhibition are not about binding but about motion?

🔗 Antagonist Binding Actively Disrupts Interleukin-1 Receptor Dynamics to Block Co-receptor Recruitment. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0017

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#DrugDiscovery #Immunology #ProteinDynamics #Inflammation #Biophysics #StructuralBiology #ComputationalBiology #Cytokines

Scientific Frontline 1d ago

Researchers engineered a new class of T cells that utilize a mechanical "catch bond" to strengthen their physical interaction with prostate cancer cells, enabling a highly targeted, potent, and sustained immune response.
#Immunology #Oncology #MolecularBiology #StructuralBiology #sflorg
https://www.sflorg.com/2026/03/imgy03212601.html

Scientists turbocharge immune cells to attack prostate cancer

A more effective T cell therapies for prostate cancer and other solid tumors

Scientific Frontline 1d ago

CryoPRISM (purification-free ribosome imaging from subcellular mixtures) is an advanced structural biology imaging technique that enables researchers to observe biomolecular complexes, such as ribosomes, within their near-natural cellular environments.
#CryoPRISM #StructuralBiology #MolecularBiology #CellBiology #Microbiology #sflorg
https://www.sflorg.com/2026/03/bio03212601.html

CryoPRISM: A new tool for observing cellular machinery in a more natural environment

The method allows researchers to observe biomolecular complexes in a quick, accurate, and budget-friendly way, providing new insights into bacterial

Scientific Frontline 2d ago

Researchers have developed and observed a light-switchable blood pressure medication that alters its molecular shape and potency when exposed to specific wavelengths of light. This advancement allows the drug's therapeutic effects to be modulated with precise timing and localization within the body.
#Photopharmacology #StructuralBiology #Biochemistry #Pharmacology #sflorg
https://www.sflorg.com/2026/03/phar03192601.html

Blood pressure-lowering drug with a light switch

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology

michael 3d ago

17-Mar-2026
Millions of #protein complexes added to #AlphaFold Database shed light on how proteins interact

https://www.eurekalert.org/news-releases/1119736

#science #structuralBiology

Millions of protein complexes added to AlphaFold Database shed light on how proteins interact

Four-way collaboration brings together world-leading AI and biological expertise to make AI-predicted protein complex structures openly available to the global scientific community

EurekAlert!

Stephan Hacker 5d ago

Can CO2 be fixed into useful feedstock chemicals by enzymes?

Congratulations to Frederik Schmidt on being award one of the @GDCh_BioChem Young Scientist Awards for his work on the biochemical and structural characterization of an iron nitrogenase with potential for this application.

https://www.nature.com/articles/s41594-023-01124-2
#Biochemistry #Chemistry #StructuralBiology #CO2Fixation

Guillaume Gaullier 5d ago

#AlphaFoldDB now has binary protein complexes!

https://www.ebi.ac.uk/about/news/technology-and-innovation/first-complexes-alphafold-database/

#AlphaFold #AlphaFold2 #StructuralBiology

Millions of protein complexes added to AlphaFold Database shed light on how proteins interact

Four-way collaboration brings together world-leading AI and biological expertise to make AI-predicted protein complex structures openly available to the global scientific community.

EMBL-EBI News

Scientific Frontline Mar 14

The freshwater #alga Trachydiscus minutus survives in extreme low-light environments by utilizing a specialized protein architecture to capture far-red light for photosynthesis, relying entirely on ordinary chlorophyll a.
#Biochemistry #StructuralBiology #Photobiology #Biology #sflorg
https://www.sflorg.com/2026/03/bchm03142601.html

Scientific Frontline

A freshwater alga captures far-red light for photosynthesis by rearranging ordinary chlorophyll

SBGrid Mar 10

Technical Notes: This month's software push includes updates to Ais, AlphaFold3, Boltzgen, Bowtie2, CellProfiler, ChimeraX, CryoMaskR, CryoSPARC-tools, Foldseek, IsoNet2, Protenix, RDKit, and upside2-md.

More here: https://sbgrid.org/software/recent/archive/2026/02/

#SBGrid #Software #StructuralBiology

SBGrid Consortium - Software Updates

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research computing.