Lab Manager / Research Associate -- Joiner Lab, Univ. of Cincinnati
University of Cincinnati

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/

#biochemistry #cellbiology #structuralbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/?fsp_sid=11881

FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.

Fork reversal fidelity declines with age. FANCM's structural landscape is an underexplored target in replication stress and genomic aging.

#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology

WRN helicase (PDB: 2QZ2) — Walker A/B and Sensor 1 motifs coordinate ADP–Mg²⁺ in the post-hydrolysis state. C-terminal tail (L514) couples helicase and exonuclease activities.

WRN loss → Werner syndrome + simultaneous acceleration of telomere attrition, epigenetic dysregulation, and stem cell exhaustion. A structural window into multi-hallmark aging.

#WRN #WernerSyndrome #StructuralBiology #LongevityBiology #DNARepair #Biogerontology #AgingHallmarks

PARP1 (PDB: 4DQY) — catalytic core resolves NAD⁺ positioning (H133/E134/Mg²⁺) and substrate interface (326–332) as structurally separable sites. E134 as the ADP-ribose acceptor base.

Age-associated DNA damage → PARP1 hyperactivation → NAD⁺ depletion → SIRT1/3 inactivation → mitochondrial dysfunction. A structurally grounded feedforward loop in biological aging.

#PARP1 #NAD #StructuralBiology #LongevityBiology #Aging #DNARepair #Biogerontology #Sirtuins

NEW PAPER!

Vanda Gunning and co. show how to target the TACC3-clathrin interaction using stapled peptides. The design was guided by structural studies. The inhibitors are cell permeable and inhibit mitosis, so have the potential for cancer therapy.
Collaboration between Bayliss, Kennedy and Royle labs.

"Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction”

https://authors.elsevier.com/sd/article/S0969-2126(26)00107-3

#biochemistry #structuralbiology #CellBiology

fly51fly (@fly51fly)

OpenFold3에서 단백질 구조의 입체형태를 제어하기 위해 잠재변수 기반의 conformational control을 제안한 연구다. 구조 예측·생성 모델의 제어 가능성을 높이는 내용으로, 단백질 모델링과 생명과학 AI 응용에 중요하다.

https://x.com/fly51fly/status/2048518363065069648

#openfold3 #proteinfolding #structuralbiology #machinelearning #arxiv

Postdoctoral fellow in molecular microbiology and immunology
NYU Grossman School of Medicine

See the full job description on jobRxiv: https://jobrxiv.org/job/nyu-grossman-school-of-medicine-27778-postdoctoral-fellow-in-molecular-microbiology-and-immunology/

#biochemistry #genetics #immunology #microbiology #structuralbiology #ScienceJobs #hiring #researc...
https://jobrxiv.org/job/nyu-grossman-school-of-medicine-27778-postdoctoral-fellow-in-molecular-microbiology-and-immunology/?fsp_sid=11425