Legacy biology treats AlphaFold as a static map. We deploy it as a kinetic targeting system.

​By classifying pathology as a Phase-State Delta (pliable vs. rigid), this blueprint integrates open-source geometric variables with wave mechanics. We mechanically target, entrain, and lyse pathological structures with zero chemical exhaust.

​The Phase-State Delta:

https://doi.org/10.17605/OSF.IO/HVYDN

​@biology @physics #AlphaFold #Bioinformatics #StructuralBiology #Mechanobiology ​#ComputationalBiology

Deploying: The Phase-State Delta

​AlphaFold has mapped the proteome; now we are defining the engine for its kinetic resolution.

​This blueprint establishes the computational bridge between static protein mapping and the Sovereign biological architecture, formalizing how we use open-source geometric variables to target and lyse pathological structures.
​https://doi.org/10.17605/OSF.IO/HVYDN

​@physics @biophysics @mechanobiology #OpenScience #Biophysics #AlphaFold #StructuralBiology #Physics ​#medicalphysics

11-Jun-2026
#Collagen, the human body’s most abundant #protein, is liquid-like inside #cells
New study overturns a 60-year-old assumption about the body's primary structural building block, opening new avenues for treating fibrosis and cancer.

https://www.eurekalert.org/news-releases/1131325

#science #nanoworld #structuralBiology

Technical Notes: May's software push includes updates to AlphaFold3, autoPROC, BoltzGen, Buster, CCP4, ChemEx, COOT, cryoCAT , DIALS, Maxit, MotionCor3, OpenFreeEnergy, OpenMM, PowerFit, pytom-match-pick, TOMOMAN, Topaz, Volume_Seg_Tool, and Warp.

More here: https://sbgrid.org/software/recent/archive/2026/05/

#SBGrid #StructuralBiology #Software

🧬 If structure determines function, how can we optimize DNA therapeutics without accurately predicting their 3D shape?

🔗 Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0127

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #DNA #ComputationalBiology #Bioinformatics #MolecularBiology #Aptamers #DNANanotechnology #GenomeEngineering #NucleicAcids

Postdoc Positions - Structural Biology, Biochemistry, Cell Biology
University of Cincinnati

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-cincinnati-27778-postdoc-positions-structural-biology-biochemistry-cell-biology/

#biochemistry #cellbiology #cryoEM #proteinbiochemistry #structuralbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-cincinnati-27778-postdoc-positions-structural-biology-biochemistry-cell-biology/?fsp_sid=12578

Molecular & Structural Biology Scientist (Internship to Hire)
BalanX Bio

See the full job description on jobRxiv: https://jobrxiv.org/job/balanx-bio-27779-molecular-structural-biology-scientist/

#cryoEM #structuralbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/balanx-bio-27779-molecular-structural-biology-scientist/?fsp_sid=12507

People of the Fediverse! I have accomplished science. Allow me to elaborate...

"Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain
required for agonist activation"

https://www.biorxiv.org/content/10.64898/2026.05.19.725324v1

#Science #Neurobiology #StructuralBiology #Biochemistry #Pharmacology #SeeMyScience #OpenScience

🦠 Could decoding bacterial regulatory proteins help us stay ahead of drug resistance?

🔗 Conserved Motifs in the Ligand-Binding Domain of TetR Family Regulators: Identification and Analysis. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0100

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #MolecularBiology #Bioinformatics #AntimicrobialResistance #DrugDiscovery #ProteinEngineering #StructuralBiology #Genomics #ComputationalBiology