🦠 A small variation in a gene can allow microorganisms to survive in hostile environments. A #CharitéBerlin study used genome-to-proteome mapping to reveal molecular associations between gene variants in yeast cells. Now in #Science:
👉 https://www.charite.de/en/service/press_reports/artikel/detail/tracking_the_impact_of_mutations
#CharitéPaper #research #science #CharitéBiochemistry #ScienceMastodon #Saccharomyces
🦠 Eine kleine Variation in einem Gen kann Mikroorganismen das Überleben in feindlicher Umgebung sichern. Eine #CharitéBerlin-Studie deckt mittels Genom-Proteom-Kartierung fundamentale molekulare Zusammenhänge bei Genvarianten von Hefezellen auf. Jetzt in #Science:
#CharitéPaper #Forschung #Wissenschaft #CharitéBiochemie #ScienceMastodon #Saccharomyces
Scientists uncover key mechanism in #evolution: Whole-#genome_duplication drives long-term #adaptation.
https://phys.org/news/2025-03-scientists-uncover-key-mechanism-evolution.html
Sometimes, the most significant scientific discoveries happen by accident. Scientists have long known that whole-genome duplication (WGD)—the process by which organisms copy all their genetic material—plays an important role in evolution. But understanding just how WGD arises, persists, and drives adaptation has remained poorly understood.
🤯 Noise-guided tuning of synthetic protein waves in living cells 😀
https://www.biorxiv.org/content/10.1101/2025.03.21.644572v1
* yeast spatiotemporal protein circuits
* genetically encoded oscillators
* clonal populations oscillate at diff. frequencies
* independ. tunable frequency/amplitude w.i. single population
#Saccharomyces #SyntheticBiology #WaveformEngineering #BioOscillators #Membranes #wafeforms
Biological systems use protein circuits to organize cellular activities in space and time, but engineering synthetic dynamics is challenging due to stochastic effects of genetic and biochemical variation on circuit behavior. Genetically encoded oscillators (GEOs) built from bacterial MinDE-family ATPase and Activator modules generate fast orthogonal protein waves in eukaryotic cells, providing an experimental model system for genetic and biochemical coordination of synthetic protein dynamics. Here, we use budding yeast to experimentally define and model phase portraits that reveal how the breadth of frequencies and amplitudes available to a GEO are genetically controlled by ATPase and Activator expression levels and noise. GEO amplitude is encoded by ATPase absolute abundance, making it sensitive to extrinsic noise on a population level. In contrast, GEO frequency is remarkably stable because it is controlled by the Activator:ATPase ratio and thus affected primarily by intrinsic noise. These features facilitate noise-guided design of different expression strategies that act as filters on GEO waveform, enabling us to construct clonal populations that oscillate at different frequencies as well as independently tune frequency and amplitude variation within a single population. By characterizing 169 biochemically distinct GEOs, we provide a rich assortment of phase portraits as starting points for application of our waveform engineering approach. Our findings suggest noise-guided design may be a valuable strategy for achieving precision control over dynamic protein circuits. ### Competing Interest Statement The authors have declared no competing interest.
Engineers find a way to protect #microbes from extreme conditions
#biotechnology #Escherichia #Ensifer #Lactobacillus #Saccharomyces
https://phys.org/news/2024-07-microbes-extreme-conditions.html
Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.
More efficient #bioethanol production might be possible using #persimmon #tannin to help #yeast thrive.
https://phys.org/news/2024-05-efficient-bioethanol-production-persimmon-tannin.html
While ethanol in alcoholic beverages impairs drinkers' motor functions, it is that same substance that can power motor vehicles in a cleaner, more sustainable manner. What is necessary for the production of ethanol is yeast, but ethanol is among the environmental factors that add stress to yeasts, hindering their growth. To promote efficient bioethanol production, scientists have been searching for substances that can help yeasts better withstand ethanol, but few effective ones have been found.
Scientific Frontline
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Charité Berlin
CellBioNews
Victoria Stuart 🇨🇦 🏳️⚧️
eLife
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