Direito Hoje Notícias22h ago
Urgência no acesso a tratamento para neuroblastoma pelo SUS é debatida no SenadoO neuroblastoma é um câncer comum em crianças pequenas, originando-se nas células nervosas. O acesso a tratamentos essenciais, como o betadinutuximabe... #AtualizaçõesLegislativas #acessoaoSUS #neuroblastoma #tratamentocâncerinfantil
https://direitohojenoticias.com.br/urgencia-no-acesso-a-tratamento-para-neuroblastoma-pelo-sus-e-debatida-no-senado/?fsp_sid=47442
NewsletterTFFeb 24

Swollen Belly in Children May Signal Neuroblastoma Cancer

Learn why a swollen belly in children could signal neuroblastoma cancer, not just bloating. Find out the key symptoms parents need to know.

#Neuroblastoma #ChildhoodCancer #ParentingTips #HealthAwareness #CancerSymptoms

https://newsletter.tf/why-a-childs-swollen-belly-might-mean-neuroblastoma-cancer/

NewsletterTFFeb 24

A swollen belly in children could be a sign of neuroblastoma cancer, a serious condition that needs medical attention. This is different from normal childhood bloating.

#Neuroblastoma #ChildhoodCancer #ParentingTips #HealthAwareness #CancerSymptoms

https://newsletter.tf/why-a-childs-swollen-belly-might-mean-neuroblastoma-cancer/

Why a Child's Swollen Belly Might Mean Cancer and What Parents Should Watch For

Learn why a swollen belly in children could signal neuroblastoma cancer, not just bloating. Find out the key symptoms parents need to know.

Scientific FrontlineDec 29
Using machine learning and a large volume of data on #genes and existing drugs, researchers at Lund University in Sweden have identified a combination of #statins and #phenothiazines that is particularly promising in the treatment of the aggressive form of #neuroblastoma
#MolecularScience #Oncology #MachineLearning #sflorg
https://www.sflorg.com/2025/12/ms12292501.html
Machine learning drives drug repurposing for neuroblastoma

The childhood cancer, neuroblastoma, affects around 15-20 children in Sweden every year.

Mr Tech KingMay 27, 2025
Circle Pharma's CID-078 shows potent preclinical anti-tumor activity in neuroblastoma, a tough pediatric cancer. This first-in-class oral macrocycle inhibitor targets cell cycle dysregulation. Exciting progress for hard-to-treat targets.
#Neuroblastoma #PediatricCancer #Biotech
ZPONZMay 11, 2025
THE EXPERT EDGE BY ZPONZ: Expert in Neuroblastoma
she help brands discover their purpose, be the change, and engage others in the compelling stories that help them drive key business results, change minds and open hearts. As a speaker, she has been highly rated or received top marks at conferences organized by IWF/Harvard/INSEAD, the Smith School of Business at Queen's University and the N.E. Dairy Association.
#ZPONZ #GetPaidForExpertise #MonetizeYourSkills #Neuroblastoma
Arjan BoltjesAug 30, 2024

"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"

https://link.springer.com/article/10.1007/s11684-024-1081-7

Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.

#scRNAseq #tumour #Neuroblastoma #pseudotime

Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma - Frontiers of Medicine

Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasis remain largely uncharacterized. In this study, we generated a transcriptomic atlas of 15 447 NB cells from eight NB samples, including paired samples of primary tumors and bone marrow metastases. We used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common ‘starter’ subpopulation that initiates tumor development and metastasis. The ‘starter’ population exhibited high expression levels of multiple cell cycle-related genes, indicating the important role of cell cycle upregulation in NB tumor progression. In addition, our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition (p-EMT) along the metastatic route from the primary site to the bone marrow. Our study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.

SpringerLink
Arjan BoltjesJun 20, 2024

While looking for #GeneExpression in tissues, specifically for #pediatric samples, I came across the #developmental #GTEx page, "a new effort to study development-specific genetic effects on gene expression from donors at each of 4 developmental windows".

https://gtexportal.org/home/aboutdGTEx

Exciting and important: for example the first age group, i.e. 0-2 years, in which our #Neuroblastoma patients often are, is mostly hard to compare to adult references and healthy controls.

#OpenScience

GTEx Portal

The Genotype-Tissue Expression (GTEx) project is an ongoing effort to build a comprehensive public resource to study tissue-specific gene expression and regulation. Samples were collected from 53 non-diseased tissue sites across nearly 1000 individuals, primarily for molecular assays including WGS, WES and RNA-seq. Remaining samples are stored in the GTEx Biobank. The GTEx Portal provides open access to data including gene expression, QTLs, and histology images.

PLOS BiologyApr 2, 2024
MYCN drives #neuroblastoma by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that #MYCN cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription #PLOSBiology https://plos.io/4amRZ03
MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription

The oncoprotein MYCN drives oncogenesis in neuroblastoma by activating the expression of genes involved in ribosome biogenesis and protein synthesis, while repressing neuronal differentiation genes, but the underlying mechanisms remain unknown. This study shows that MYCN cooperates with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription.

katch wreckFeb 28, 2024

"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"

https://elifesciences.org/articles/86823

Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs

Volatile compounds from microbes and food alter epigenetic states by inhibiting histone deacetylases and alter gene expression, slow degeneration in Huntington’s model flies, and slow proliferation of a neuroblastoma cell line.

eLife