Else Kröner-Fresenius-Stiftung🧠 Wie lässt sich das Wachstum aggressiver Tumore des Gehirns & Rückenmarks stoppen?
Das Projekt MOMENT-MYCN erforscht eine neue, bislang unheilbare Form von #Ependymomen – mit Fokus auf das Krebsgen #MYCN und neue Therapieansätze. 🔬✨
PLOS BiologyMYCN drives #neuroblastoma by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that #MYCN cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription #PLOSBiology https://plos.io/4amRZ03
MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
The oncoprotein MYCN drives oncogenesis in neuroblastoma by activating the expression of genes involved in ribosome biogenesis and protein synthesis, while repressing neuronal differentiation genes, but the underlying mechanisms remain unknown. This study shows that MYCN cooperates with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription.
Arjan BoltjesFurther presentations on #MYCN binding not just DNA but also RNA, #MKK7 mutations in high risk #neuroblastoma, #BARD1 mutations,
DNA damage repair deficiency incl. enhanced #metastasis.
Plus 1 minute pitches for posters, including a #poem. 👌