preLightsMetastatic Matchmaking: CD24 Brings Tumour Cells and Platelets Together
Check out this excellent #preLight from Harvey Roweth, which includes answers and future directions from the authors of the preprint. ⬇️
ƧƿѦςɛ♏ѦਹѤʞNovel keyhole technique used to remove head tumour:
https://www.bbc.com/news/articles/c98yg1n9j83o
#medical #surgery #operation #tumour #cranium #medicine
https://www.bbc.com/news/articles/c98yg1n9j83o
#medical #surgery #operation #tumour #cranium #medicine
Heliograph"Researchers from RMIT University in Australia and Indian institutions unveiled a novel gold-based drug that shows significant promise in the fight against cancer. The drug has demonstrated the ability to slow #tumour growth while selectively targeting cancer cells more effectively than traditional #chemotherapy agents."
https://interestingengineering.com/health/gold-based-drug-slows-cancer
https://interestingengineering.com/health/gold-based-drug-slows-cancer
Arjan Boltjes"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"
https://link.springer.com/article/10.1007/s11684-024-1081-7
Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.
Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma - Frontiers of Medicine
Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasis remain largely uncharacterized. In this study, we generated a transcriptomic atlas of 15 447 NB cells from eight NB samples, including paired samples of primary tumors and bone marrow metastases. We used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common ‘starter’ subpopulation that initiates tumor development and metastasis. The ‘starter’ population exhibited high expression levels of multiple cell cycle-related genes, indicating the important role of cell cycle upregulation in NB tumor progression. In addition, our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition (p-EMT) along the metastatic route from the primary site to the bone marrow. Our study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.
earthlingAnia, National Cancer Institute, Kyiv, 2015
“Ania is a six-year-old girl who grew up in a small town outside the exclusion zone. People who grew up in the contaminated areas are having #children, and there’s a lot of genetic mutation and illness related to radiation. Ania was suffering from a malignant bone #tumour. She was a strong, positive child, passionate about art and drawing. The doctors told me she had little hope of survival. I don’t know if she is still alive or not.”
Paul Guinnessy
Matt WillemsenAncient Egyptians tried to treat cancer 4,000 years ago, cut-marked skull indicates
https://www.livescience.com/archaeology/ancient-egyptians/ancient-egyptians-tried-to-treat-cancer-4000-years-ago-cut-marked-skull-indicates #archaeology #egypt #medicine #cancer #surgery #tumour
https://www.livescience.com/archaeology/ancient-egyptians/ancient-egyptians-tried-to-treat-cancer-4000-years-ago-cut-marked-skull-indicates #archaeology #egypt #medicine #cancer #surgery #tumour
Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."
Giuseppe Michieli#Tasmaniandevil facial #tumour hasn’t let up https://cosmosmagazine.com/nature/animals/tasmanian-devil-facial-tumour-study/
In 2021, a study showed that 25 years of #DFTD’s spread had a massive impact on the Tasmanian devil population. The number of devils on the island of Tasmania shrank from 53,000 in 1996 to only 17,000 in 2021. The same study suggested that DFTD covered more than 90% of the devils’ range in Tasmania. As a result, #Australia’s largest remaining marsupial carnivore was listed as endangered.
InvisibleShoe