katch wreck"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"
Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs
Volatile compounds from microbes and food alter epigenetic states by inhibiting histone deacetylases and alter gene expression, slow degeneration in Huntington’s model flies, and slow proliferation of a neuroblastoma cell line.