📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays.

Check it out in @acs.org ACS Central Science https://doi.org/10.1021/acscentsci.4c02124

#glycotime #clickchemistry #luminex

Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.

#GPCR #clickchemistry

https://biorxiv.org/content/10.1101/2024.10.31.621373v1

Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)

New ribozyme can make #RNA molecules accessible for #clickchemistry in living cells https://phys.org/news/2023-09-ribozyme-rna-molecules-accessible-click.html

Damn this is hot - imagine the possibilities for single sell #RNAseq @nanopore
#sequencing

A new method to detect native #glycoRNA from Ryan Flynn's lab.

#RNA #mRNA #ClickChemistry

https://www.biorxiv.org/content/10.1101/2023.02.26.530106v1?med=mas

Nanotech Enzyme Process Boosts T-Cell Cancer Therapies

A #bioengineering team devised techniques for feasibly adding cancer-killing #enzymes to engineered #immune cells that in lab mice kill solid #tumor and blood #cancer cells.

https://sciencebusiness.technewslit.com/?p=44317

#News #Science #Engineering #Biotechnology #Chemistry #ClickChemistry #Nanotechnology #Cytokines #Preclinical #University

Sorry to the reviewer who chose an arbitrary out-of-subject field (chemistry) while trying to argue against the significance of my sister's paper. You couldn't have known we were related, but I got to squee at her about click chemistry for 10 minutes to describe why tool development is important for future discovery.

#SorryNotSorry #Science #ClickChemistry #ChemicalBiology #ChemiVerse

What a great, accessible summary of the work awarded the 2022 Nobel Prize in Chemistry (@[email protected], Meldal, Sharpless) by @[email protected] and @[email protected]!

#clickchemistry

https://www.nejm.org/doi/pdf/10.1056/NEJMcibr2213596?articleTools=true

Great piece by the very talented
Claire O'Connell out on The Irish Times @irishtimes celebrating the #ChemNobel to #ClickChemistry and #BioOrthogonalChemistry with some enthusiastic feedback from me and Andrew Kellet

@bertozzi I hope you'll like it 😊👏👏👏

https://www.irishtimes.com/science/2022/12/01/click-and-collect-the-nobel-prize-in-chemistry/

#glycotime #chemiverse #chemistry #Nobel

This 2021 article was shared by RSC chemical biology for #FluorescenceFriday:
https://pubs.rsc.org/en/content/articlelanding/2021/cb/d1cb00002k

Tbh I was not aware of click-based amplification techniques and this paper hasn't been cited yet or gained much attention otherwise.

The research this was based on has been applied only to nucleic acid imaging:
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201700209

So the question is has anyone tried this? Does it work and is it useful?

#clickchemistry #bioimaging #bioorthogonal