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"Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET" in #Structure

🔗 https://doi.org/10.1016/j.str.2025.01.011

🧵 #GPCR #mGluR🧼#detergents #cholesterol
🔬 #smFRET
💻🧪 #MD #mutants

Congrats to C. Banerjee, B. Liauw, and R. Vafabakhsh!

Our preprint is up! Take a look if you like kinesin, microtubule transport, single molecule FRET or biophysics. It’s a bit of shift to how we’ve been used to thinking about kinesin-1 regulation as we try to get a handle on its conformational dynamics. Super proud of to have this milestone out in the world and all the hard work it represents from everyone involved.
#kinesin #microtubules #biophys #smFRET #SingleMolecule #AxonalTransport https://biologists.social/@TwelvetreesLab/113691748206473977
Twelvetrees Lab (@[email protected])

Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo http://biorxiv.org/cgi/content/short/2024.12.20.629623v1?rss=1

biologists.social

Check our new preprint !
Triple orthogonal labeling with 2 unnatural aminoacids + 1 SNAP-Tag for 3 color #smFRET.
We resolve a new intermediate in the activation of metabotropic glutamate receptor 2.

#GPCR #clickchemistry

https://biorxiv.org/content/10.1101/2024.10.31.621373v1

Collaboration with Jean Philippe Pin & Philippe Rondard (IGF Montpellier) & Don Lamb (LMU Munich)

You are driving to St. Louis from England?? The boxes better have flotation devices 😂😂
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RT @EI_science
By delivering the EI-FLEX, we're not only providing them with a powerful tool 🛠️ for #smFRET research, but we're also promoting the values of #OpenScience and #collaboration.

We can't wait to see the #innovative discoveries 💡 that will emerge from this partnership! https://twitter.com/Exciting_Ben/status/1638881684505636865
https://twitter.com/EI_science/status/1638883228814811138

Tweet / Twitter

Twitter
Only 2 weeks left to apply for the 3 postdoctoral positions available in our team, in the fields of atomic force microscopy #AFM, single molecule fluorescence spectroscopy (#smFRET) and #DNAorigami.
More info & application here
https://integrativebiophysicsofmembranes.wordpress.com/2022/11/28/now-hiring/
Now hiring !

Several of our research projects have been recently funded by ANR & FranceBioImaging. Therefore we are now looking for two candidates, to fulfill the following positions : Postdoc position Post…

Team Integrative Biophysics of Membranes

Our team is hiring ! We are looking for three postdoctoral researchers in the field of atomic force microscopy #AFM, single molecule fluorescence spectroscopy (#smFRET) and #DNAorigami.
More info & application process here.
https://integrativebiophysicsofmembranes.wordpress.com/2022/11/28/now-hiring/

Please spread the info !

Now hiring !

Several of our research projects have been recently funded by ANR & FranceBioImaging. Therefore we are now looking for two candidates, to fulfill the following positions : Postdoc position Post…

Team Integrative Biophysics of Membranes
Time for #introduction.
My name is Emmanuel « Manu » Margeat.
I develop and use single molecule fluorescence , including #smFRET, #FCS, and #SPT.
My research focuses on elucidating the structural dynamics and the interactions of #membrane #proteins, in vitro and in living cells.
I am strongly involved in research management, serving as deputy director of the #CBS, the Centre de Biologie Structurale in Montpellier , or as Council member for the french and the american Biophysical Society #BPS.
Hello #ScienceMastodon I am a biophysicist and leader of an active research group in the field of #singlemolecule studies, #smFRET #singlemoleculetracking and #superresolution microscopy at Ulm University. Looking forward to great scientific exchange