Mastodawn

A breakthrough class of spontaneously blinking fluorescent dyes that enable ultra-detailed, super-resolution microscopy of living cells without causing cellular damage.
#CellBiology #Oncology #Bioengineering #ChemicalBiology #sflorg
https://www.sflorg.com/2026/04/cbio04162601.html

New imaging tools help cancer researchers see inside living cells

OHSU scientist helps develop imaging strategy that unlocks next-generation dyes to study how cancer cells grow, move, change in real time

Kirtikumar Jadhav 1d ago

New paper out: Meet Psysol 3—a novel #cyclotide #NaturalProduct from Psychotria solitudinum. A #cystine_knot #peptide that potently inhibits prolyl oligopeptidase, expanding chemical space for POP #pharmacology and #DrugDiscovery. #ChemicalBiology @univienna #PeptAIDes #ZK81B @fwf

https://doi.org/10.1007/s13659-026-00598-z

Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase - Natural Products and Bioprospecting

Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are a notable class, yet their distribution, diversity, and targets remain underexplored. Here, eleven tropical Psychotria species were screened for cyclic cysteine-rich peptides, with extracts showing concentration-dependent inhibition of human prolyl oligopeptidase (POP). Peptidomics combining mass spectrometry and transcriptome mining revealed multiple inhibitory peptides. From Psychotria solitudinum, which contained 37 peptides, a novel peptide (psysol 3) was purified and sequenced. Its synthetic analogue inhibited POP with an IC50 of ~ 1.3 µM. Sequence analysis and synthetic probes identified loop 3 as the inhibitory motif. Psysol 3 is a new probe for POP pharmacology and future structure–activity studies.

SpringerLink

jobRxiv Mar 29

NTT Research Assistant Professor or Postdoctoral Scholar
Temple University

See the full job description on jobRxiv: https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/

#biochemistry #cellbiology #chemicalbiology #proteinengineering #Proteinexpressionandpurification #ScienceJobs #hiring #research
https://jobrxiv.org/job/temple-university-27778-ntt-research-assistant-professor-or-postdoctoral-scholar/?fsp_sid=10761

NTT Research Assistant Professor or Postdoctoral Scholar

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobRxiv

Scientific Frontline Mar 25

Biomolecular condensates are concentrated molecular communities of DNA, RNA, and proteins within cells that can actively drive and regulate the cellular metabolic cycle. Recent findings demonstrate that these condensates can facilitate the formation of crucial carbon-nitrogen bonds to create new molecules, a critical first step in protein formation.
#CellularBiochemistry #BiomedicalEngineering #MolecularCellBiology #ChemicalBiology #sflorg
https://www.sflorg.com/2026/03/bchm03252601.html

Biomolecular condensates mediate C–N bond formation

Biomolecular condensates drive carbon-nitrogen bonds

Scientific Frontline Mar 3

Researchers developed a bioorthogonal fluorescence probe and a matching engineered reporter enzyme that selectively activate at targeted #tumor sites, enabling high-contrast tumor visualization with minimal background noise.
#Oncology #Biology #ChemicalBiology #sflorg
https://www.sflorg.com/2026/03/ongy03032601.html

Precision tumor imaging with a fluorescence probe and engineered enzymes

Selective activation at cancer sites enables easy visibility of tiny lesions in a mouse model

Cell Chemical Biology Feb 19

New issue alert! The February edition of Cell Chemical Biology is here with must-read studies and a review. Which article will you read first? Tell us after you check it out: https://www.cell.com/cell-chemical-biology/current?utm_source=dlvr.it&utm_medium=mastodon #ChemicalBiology

Suweb Reza Dec 14

Pseudopterosin origin in Symbiodinium sp.
• 🔬 19±4 µg/10⁶ cells concentration in algal cells.

#Pseudopterosin #Symbiodinium #CoralResearch #ChemicalBiology #Pub2Post https://tnyp.me/jIqjitIQ/m

CSBJ Dec 5

🤖 What happens when we let a Transformer model, not a docking engine, judge protein–ligand affinity?

🔗 DrugForm-DTA: Towards real-world drug-target binding affinity model. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.023

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #DrugDiscovery #Cheminformatics #StructuralBiology #ChemicalBiology #DrugTargetAffinity #QSAR

CSBJ Nov 30

🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?

🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation

LED3hub Aug 23, 2025

Exciting #PhD Opportunity in #DrugDiscovery at Leiden University!

The group of Madeline Kavanagh of the @LED3hub is thrilled to announce a new PhD position at the intersection of #ChemicalBiology and #Immunology.

https://www.universiteitleiden.nl/en/vacancies/2025/q3/15942-phd-candidate-in-chemical-biology-and-immuno-metabolism
#ChemBio #Chemistry

PhD Candidate in Chemical Biology and Immuno-metabolism

The Faculty of Science Leiden, the Leiden Institute of Chemistry and Leiden Institute of Biology are looking for a PhD candidate to pursue research on the development of drugs modulating immunometabolism. Immune dysregulation contributes to many human diseases, including cancer, cardiovascular…

Leiden University