Mastodawn

Cell Chemical Biology Jun 20, 2024

Induced proximity in biology and therapeutics: Read the editorial to learn more about Induced Proximity and the articles you will find in the Special Issue. #PROTACs #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #Epigenetics #glycoRNA #photocatalytic #TPD #LyTACs https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00218-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Elisa Fadda-🔺Nov 7, 2023

Ryan Flynn @raflynn does it again! 👏👏👏

Evidence of RNA base acp3U as an attachment site for N-glycans in #glycoRNA by coupling native glycoRNA labeling (rPAL) w/SWATH-MS

Phenomenal #glycotime by Ryan Flynn and coworkers live on #bioRxiv ⬇️ 🤩🤩😎
https://www.biorxiv.org/content/10.1101/2023.11.06.565735v1

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Nov 6, 2023

And a new preprint from
from Ryan Flynn, Caroline Bertozzi
on #glycoRNA
Chemical/molecular oriented, they characterize the chemical modification on the RNA that allow N-glycan binding.
"The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA"
https://www.biorxiv.org/content/10.1101/2023.11.06.565735v1

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Oct 31, 2023

🎯🐠 I've been away for a while. But here:
I wrote a blog post on "Imaging mRNA modifications in situ"

Featuring: m6AISH-PLA, ARPLA (on #glycoRNA) & DART-FISH.

#smFISH #m6A #RNA #mRNA #RNAmodifications #microscopy #imaging #singlemolecule

https://greenfluorescentblog.wordpress.com/2023/10/31/imaging-mrna-modifications-in-situ/

Imaging mRNA modifications in situ

There are at least 170 known chemical modifications on RNA molecules in all organisms. Most of these modifications are on tRNAs, rRNAs and small RNAs. But over the past two decades, researchers fou…

greenfluorescentblog

Gal Haimovich 😷🔬☣🏳️‍🌈🏳️‍⚧Feb 27, 2023

A new method to detect native #glycoRNA from Ryan Flynn's lab.

#RNA #mRNA #ClickChemistry

https://www.biorxiv.org/content/10.1101/2023.02.26.530106v1?med=mas