Can the functions of #metalloenzymes be further improved using non-canonical amino acids?
In her talk at #Biochemistry2026, Alexandra Deliz Liang talked about the usage of genetic code expansion in order to improve the activity of metalloenzymes using e.g. hydrophobic tuning.
https://www.biorxiv.org/content/10.1101/2025.02.09.636911v1
#Chemistry #ChemBio #Biochemistry #BioinorganicChemistry #ProteinEngineering
CC: @gdch, @GDCh_BioChem
Alexandra Deliz Liang gave an exciting talk at #Biochemistry2026. She talked about her group's research on "Metalloenzyme engineering with genetic code expansion".
https://www.biorxiv.org/content/10.1101/2025.02.09.636911v1
#Biochemistry #Chemistry #ChemBio #ProteinEngineering #Metalloenzyme
CC: @gdch
Synthetic Biology for Light-Activated Smart Materials
Design and characterise light-responsive proteins and demonstrate light-controlled behaviour of cell-free biology in materials.
#SynBio, #StructuralBiology, #ProteinEngineering, and #biomaterials.
#PhD Studentships are fully funded for 4yrs, with minimum of 3 months at the industry partner. Funding for home (UK) students = tax-free stipend (indicative in year 1 in 2026-27 (£21,383), research costs and tuition fees.
https://www.findaphd.com/phds/project/synthetic-biology-for-light-activated-smart-materials/?p193808
How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures
A bioprocess engineer's journey into machine learning and why the pharmaceutical industry desperately needs this bridge When I tell people I work in bioprocess engineering, I usually get blank stares. When I explain that I help manufacture proteins in giant tanks for therapeutic use, the response is often: "Oh, like brewing beer?" Not quite. But close enough. What I don't usually mention is that I've been teaching myself machine learning on nights and weekends. Not because it's trendy, but […]Inito Secures $29M to Build Next-Gen AI-Engineered Home Diagnostics
#NewsUpturn #Inito #SeriesBFunding #HealthTech #AIinHealthcare #AtHomeDiagnostics #AIDiagnostics #DigitalHealth #FemTech #FertilityTech #BiotechInnovation #ProteinEngineering #SyntheticAntibodies #BertelsmannIndiaInvestments #FiresideVentures #StartupFunding #HealthcareInnovation #HormoneHealth #MedicalAI #IndiaStartups #DeepTech #HealthMonitoring #ConsumerHealthTech
https://newsupturn.com/inito-secures-29m-to-build-next-gen-ai-engineered-home-diagnostics/
Inito Raises $29M Series B to Advance AI-Powered At-Home Diagnostics
#TycoonWorld #Inito #SeriesBFunding #HealthTech #AIinHealthcare #AtHomeDiagnostics #AIDiagnostics #DigitalHealth #FemTech #FertilityTech #BiotechInnovation #ProteinEngineering #SyntheticAntibodies #BertelsmannIndiaInvestments #FiresideVentures #StartupFunding #HealthcareInnovation #HormoneHealth #MedicalAI #IndiaStartups #DeepTech
https://tycoonworld.in/inito-raises-29m-series-b-to-advance-ai-powered-at-home-diagnostics/
🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?
🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI
✨ Is it time to rethink allosteric site prediction using internal protein nanoenvironments?
🔗 Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.036
📚 CSBJ: https://www.csbj.org/
#DrugDiscovery #ComputationalBiology #StructuralBiology #ProteinEngineering #Biophysics #Cheminformatics
Fully Funded PhD Scholarship (Spring/Fall 2026)
Nanyang Technological University
Join us to work on AI for drug discovery!
See the full job description on jobRxiv: https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/
#deeplearning #drugdiscovery #largelanguagemodels #proteinengineering #RNAtherapeutics #ScienceJ...
https://jobrxiv.org/job/nanyang-technological-university-27778-fully-funded-phd-scholarship-spring-fall-2026/?fsp_sid=5646
💧 Is your MD simulation lying to you because of the water model you picked?
🔗 Impact of water models on the structure and dynamics of enzyme tunnels. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.051
📚 CSBJ: https://www.csbj.org/
#ComputationalBiology #MolecularDynamics #Enzymology #StructuralBiology #ProteinEngineering #Biophysics #WaterModels #EnzymeTunnels #MolecularSimulation #ProteinDynamics
Stephan Hacker
GDCh Division of Biochemistry
Tom Howard
Kemal
News Upturn
Tycoon World
CSBJ
jobRxiv