FrankyJan 30, 2025

Staal van asteroïde Bennu slaat wetenschappers met verstomming: “Dit hebben we nog nooit eerder gezien”

https://www.hln.be/weer-en-wetenschap/staal-van-asteroide-bennu-slaat-wetenschappers-met-verstomming-dit-hebben-we-nog-nooit-eerder-gezien~adfb813f/

We zijn dus nog niet aan 't einde van 't verhaal ✨️

#Bennu #Asteroïde #dna #nucleotide

Staal van asteroïde Bennu slaat wetenschappers met verstomming: “Dit hebben we nog nooit eerder gezien”

De eerste analyse van het gesteente en stof dat de ruimtesonde OSIRIS-REx van NASA in 2020 van de asteroïde Bennu terug naar de aarde bracht, tonen een nooit eerder geziene rijkdom aan bouwstenen voor leven in buitenaards materiaal. Dat melden twee studies die vandaag zijn verschenen in Nature en Nature Astronomy: “Dit is het soort ontdekking dat je hoopt te doen.”

hln.be
Giuseppe MichieliSep 18, 2024

#Evolution and mutational #landscape of highly pathogenic avian #influenza strain A(#H5N1) in current #outbreak in #USA & global landscape, Virology: https://www.sciencedirect.com/science/article/abs/pii/S0042682224002678?via%3Dihub

The study evaluated the virus evolution, divergence, #transmission #patterns, and infection patterns. The study also illustrated entropy diversity in the #genome, #nucleotide diversity in the genome, and mutational landscape.

Evolution and mutational landscape of highly pathogenic avian influenza strain A(H5N1) in the current outbreak in the USA and global landscape

The emergence of highly pathogenic avian influenza strain A (H5N1) in the USA is a high concern. Here, we illustrated the evolution, divergence, trans…

CellBioNewsJul 23, 2024

New liquid single #nucleotide polymorphism chip can enhance #rubber #tree #breeding.

#SNP #HbGBTS80K #genomics #agriculture

https://phys.org/news/2024-07-liquid-nucleotide-polymorphism-chip-rubber.html

New liquid single nucleotide polymorphism chip can enhance rubber tree breeding

A research team developed and validated a liquid single nucleotide polymorphism (SNP) chip named "HbGBTS80K," which includes 80,080 SNPs evenly distributed across 18 chromosomes. This SNP chip effectively distinguished 404 rubber accessions into four groups in population genetic diversity analysis and detected the major gene HbPSK5 in GWAS for the number of laticifer rings. The HbGBTS80K chip is a valuable tool for accelerating functional studies and molecular breeding in rubber trees, addressing the inefficiencies of traditional breeding methods.

PLOS BiologyJul 15, 2024
#Proteasome regulation is disrupted in human #NGLY1 deficiency. @nlehrbach @gary_ruvkun &co find that in NGLY1-deficient #Celegans this depends on #nucleotide availability, suggesting that nucleotide restriction might mitigate such diseases #PLOSBiology https://plos.io/4cViY3y
Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans

Regulation of the proteasome is disrupted in the rare genetic disease known as NGLY1 deficiency. This manuscript finds that proteasome dysfunction in NGLY1-deficient C. elegans depends on nucleotide availability, indicating an unexpected regulatory crosstalk between nucleotide metabolism and protein turnover, and suggesting that interventions to alter nucleotide availability might mitigate proteasome insufficiency in diseases associated with proteasome dysfunction.

katch wreckJun 21, 2024

"Here, we studied the genomic architecture of DUP-TRP/INV-DUP by investigating the DNA of 24 patients identified by array comparative #genomic hybridization (aCGH) on whom we found evidence for the existence of 4 out of 4 predicted structural variant (SV) haplotypes..The point of template #switching in 4 samples was shown to be a segment of ∼2.2–5.5 kb of 100% #nucleotide similarity within inverted repeat pairs...inverted low-copy repeats act as recombinant substrates"

https://www.cell.com/cell-genomics/fulltext/S2666-979X(24)00174-5

micrordtMay 5, 2024

Unraveling the Mysteries of DNA: The Blueprint of Life

#BasePairs, #DNA, #Genetics, #MolecularBiology, #Nucleotide #RDT In the intricate tapestry of life, one molecule stands out as the ultimate architect – DNA, or deoxyribonucleic acid. Often…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/05/05/unraveling-the-mysteries-of-dna-the-blueprint-of-life/

Unraveling the Mysteries of DNA: The Blueprint of Life

#BasePairs, #DNA, #Genetics, #MolecularBiology, #Nucleotide #RDT In the intricate tapestry of life, one molecule stands out as the ultimate architect – DNA, or deoxyribonucleic acid. Often…. Medica…

Medical Microbiology & RDT Labs
micrordtApr 27, 2024

Nucleic Acid Structure

#BasePairs, #DNA, #DoubleHelix, #NucleicAcid, #Nucleotide, #RNA #Genetics The nucleic acid, DNA and RNA are build from nucleotides monomers. The nucleotides link together by phosphodiester bonds to make…. Medical Microbiology & Recombinant DNA Technology (RDT) Labs | Read More -

https://micrordt.wordpress.com/2024/04/27/nucleic-acid-structure/

Nucleic Acid Structure

#BasePairs, #DNA, #DoubleHelix, #NucleicAcid, #Nucleotide, #RNA #Genetics The nucleic acid, DNA and RNA are build from nucleotides monomers. The nucleotides link together by phosphodiester bonds to…

Medical Microbiology & RDT Labs
micrordtApr 27, 2024

Deciphering the Blueprint of Life: Exploring the Structure of DNA

#Adenine, #Blueprint, #Cytosine, #DeoxyriboseSugar, #DNA, #DNACoiling, #DoubleHelix, #Guanine, #Histone, #MajorGroove, #MinorGroove, #NitrogenousBases, #Nucleotide, #Phosphate, #StructureOfDNA, #Thymine, #WatsonAndCrick #Biochemistry, #Genetics The discovery of the structure of DNA stands as one of the most significant milestones in the history of science. Deoxyribonucleic acid, or DNA, is the molecule…

https://micrordt.wordpress.com/2024/04/27/deciphering-the-blueprint-of-life-exploring-the-structure-of-dna/

Deciphering the Blueprint of Life: Exploring the Structure of DNA

#Adenine, #Blueprint, #Cytosine, #DeoxyriboseSugar, #DNA, #DNACoiling, #DoubleHelix, #Guanine, #Histone, #MajorGroove, #MinorGroove, #NitrogenousBases, #Nucleotide, #Phosphate, #StructureOfDNA, #Th…

Medical Microbiology & RDT Labs
Scientific FrontlineMar 12, 2024
#Tumors can carry #mutations in hundreds of different #genes, and each of those genes may be mutated in different ways — some mutations simply replace one #DNA #nucleotide with another, while others insert or delete larger sections of DNA.
#Biology #Genetics #Cancer #sflorg
https://www.sflorg.com/2024/03/bio03122401.html
Scientists develop a rapid gene-editing screen to find effects of cancer mutations

Scientists develop a rapid gene-editing screen to find effects of cancer mutations

katch wreckJul 9, 2023

`Furthermore, we show that 5′-FAD capping protects RNA from RIG-I mediated innate #immune recognition but does not stabilize the HCV #RNA. These results establish #capping with cellular metabolites as a novel #viral RNA-capping strategy, which could be used by other viruses and affect anti-viral treatment outcomes and persistence of #infection.`

https://www.nature.com/articles/s41586-023-06301-3

#interesting #virology #medicine #molecularBiology #molecularBio #biology #ribonucleotide #nucleotide #immunology #pathology

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide - Nature

Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides protection against the host innate immune response.

Nature