PLOS Biology4d ago
Some #bacteria polymerize excess carbon into polyhydroxybutyrate (PHB), a biodegradable storage polymer. This study shows that #PHB -producing bacteria kill #Celegans nematodes by disrupting pharyngeal & intestinal function @PLOSBiology https://plos.io/4cFAwDz
PLOS Biology4d ago
Can changes in the #proteome be transmitted from parents to offspring? @betowbin &co study #intergenerational effects of #DietaryRestriction in #Celegans, showing that maternal mTORC1 governs transfer of #ribosomes, so modulating growth & development @PLOSBiology https://plos.io/4tMpQJe
Albert CardonaMar 25

RE: https://biologists.social/@biorxiv_neursci/116285752876943074

I'm glad you asked, @tuthill

#neuroscience #Drosophila #Celegans

Molecular Biology & EvolutionNov 20

Aharonoff et al. show that dosage compensation mechanisms continue to evolve in species with shared X chromosome ancestry, and that the process of evolving chromosome-wide gene regulatory mechanisms is constrained.

๐Ÿ”— https://doi.org/10.1093/molbev/msaf270

#evobio #molbio #celegans

Parallel Evolution of X Chromosome-Specific Structural Maintenance of Chromosomes Complexes in Two Nematode Lineages

Abstract. Mechanisms of X chromosome dosage compensation have been studied in model organisms with distinct sex chromosome ancestry. However, the diversity

OUP Academic
eLifeOct 27
NeuroSC is a new #OpenAccess tool that lets researchers interactively explore neuronal morphology, membrane contacts and synaptic connectivity across #CElegans development.
https://elifesciences.org/articles/103977?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Albert CardonaOct 24

"The dopaminergic system of Caenorhabditis elegans", Muralidhara and Hardege, 2025
https://royalsocietypublishing.org/doi/10.1098/rsos.250843

That's the review I was waiting for โ€“ finally I have the field laid out to write the reinterpretation of part of the worm's pharyngeal ring โ€“ aka the brain โ€“ as an antennal lobe and a mushroom body.

#Celegans #neuroscience #dopamine

Show threadAlbert CardonaOct 16, 2025

@brembs

For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.

Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.

#Celegans #neuroscience #connectomics

eLifeOct 11, 2025
When its meal turns toxic, the tiny worm #CElegans shuts down digestion thanks to a single protein that links its โ€œtasteโ€ neurons to the gut.
https://elifesciences.org/digests/104028/gut-feeling?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Gut feeling

C. elegans uses a protein located in specific neurons to detect toxic food and shut down the digestive system.

eLife Sciences Publications, Ltd
PLOS BiologyOct 9, 2025
Nicotine exposure elicits diverse behavioral changes. This study shows that in #Celegans, chronic #nicotine exposure couples reversal behaviors to rhythmic body contractions by modulating the sensitivity of a mechanosensory-motor circuit
@PLOSBiology plos.io/4o2CWyS
PLOS BiologyOct 1, 2025
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @PLOSBiology https://plos.io/4nU79QF