katch wreck`Furthermore, we show that 5′-FAD capping protects RNA from RIG-I mediated innate #immune recognition but does not stabilize the HCV #RNA. These results establish #capping with cellular metabolites as a novel #viral RNA-capping strategy, which could be used by other viruses and affect anti-viral treatment outcomes and persistence of #infection.`
https://www.nature.com/articles/s41586-023-06301-3
#interesting #virology #medicine #molecularBiology #molecularBio #biology #ribonucleotide #nucleotide #immunology #pathology
Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide - Nature
Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides protection against the host innate immune response.