Structural basis for NONO-specific modification by the α-chloroacetamide compound (R)-SKBG-1 https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00429-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00426-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00027-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Exporter Mdr1 as an importer is an achilles’ heel for combating drug-resistant Candida https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00029-2?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00023-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00026-7?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00022-X?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Deciphering phosphorylation TACtics: Advances in phosphorylation targeting strategies and bifunctional modalities https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(25)00428-3?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Decoding E1-E2 specificity: How UBA6 prioritizes BIRC6 for ubiquitin conjugation https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00030-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Beyond a degrader: VHL reprograms hypoxic metabolism https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00031-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon