Online now! Lysine methylation as a bidirectional switch https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00192-3?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #chembiol

Online now! Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00191-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #chembiol

Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00154-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Covalent PPARγ inverse agonism by FX-909 reveals mechanistic insights into therapeutic targeting of PPARγ/RXRα-activated urothelial carcinoma https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00152-2?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00185-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00157-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00151-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Giredestrant immobilizes the estrogen receptor to exert potent antitumor efficacy against ER-active breast cancers https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00143-1?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

Mechanisms and interventions of epigenetic aging https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00186-8?rss=yes&utm_source=dlvr.it&utm_medium=mastodon

A defense-like route to gene transfer agent release https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(26)00193-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon