Cell Chemical BiologyInduced proximity in biology and therapeutics: Read the editorial to learn more about Induced Proximity and the articles you will find in the Special Issue. #PROTACs #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #Epigenetics #glycoRNA #photocatalytic #TPD #LyTACs https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00218-6?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Haplogroup News 
Shared genetics and causal associations between COVID-19 and multiple sclerosis
"Neuroinflammation caused by COVID-19 negatively impacts brain metabolism and function, while preexisting brain pathology may make individuals more vulnerable to the adverse consequences of COVID-19. We used summary statistics from genome-wide association studies (GWAS) to perform Mendelian randomization (MR) analyses, thus assessing potential associations between multiple sclerosis (MS) and three COVID-19 outcomes (SARS-CoV-2 infection, COVID-19 hospitalization, and critical COVID-19). Genome-wide risk genes were compared between the GWAS datasets on hospitalized COVID-19 and MS. Literature-based analysis was conducted to construct molecular pathways connecting MS and COVID-19. The MR analyses indicated that genetic liability to MS confers a causal effect on hospitalized COVID-19 (OR: 1.09, 95% CI: 1.03-1.16) but not on SARS-CoV-2 infection (1.03, 1.00-1.05). Genetic liability to hospitalized COVID-19 confers a causal effect on MS (1.15, 1.02-1.30). Hospitalized COVID-19 and MS share five risk genes within two loci, including TNFAIP8, HSD17B4, CDC37, PDE4A, and KEAP1. Pathway analysis identified a panel of immunity-related genes that may mediate the links between MS and COVID-19. Our study suggests that MS was associated with a 9% increased risk for COVID-19 hospitalization, while hospitalized COVID-19 was associated with a 15% increased risk for MS. Immunity-related pathways may underlie the link between MS on COVID-19. This article is protected by copyright. All rights reserved."
https://pubmed.ncbi.nlm.nih.gov/36571271/ #COVID19 #MultipleSclerosis #TNFAIP8 #HSD17B4 #CDC37 #PDE4A #KEAP1
