Check out today's new TTRPGkids site post, an interview with Dr. Springle from Play on Words about how she's using TTRPGs in her speech therapy practice!
Dr. Springle shares her methods, how TTRPGs uniquely facilitate speech therapy, and some favorite moments from her game.
Find the interview on the TTRPGkids site, and happy gaming!
Reason this briefing matters for mental health professionals: It highlights a mechanistic link between immune activation in the brain and amyloid clearance, which may inform understanding of neuroinflammatory processes involved in cognitive decline and dementia. Awareness of how biological targets influence neural health can illuminate potential avenues for interdisciplinary collaboration and referral strategies when addressing memory-related concerns in clients.
Article Title: Scientists finally reveal how this Alzheimer’s drug really works
Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/03/260317064457 dot htm
#alzheimers #immuneactivation #microglia #neurodegeneration #therapeutics
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Single Dose of DMT Rapidly Reduces Symptoms of Major Depression
Small Phase IIa study [34 subjects] but some interesting points
"intravenous DMT has a half-life of around five minute"
and
"A single dose of DMT with psychotherapeutic support produced a rapid, significant reduction in depressive symptoms, sustained up to three months,"
https://www.sciencealert.com/single-dose-of-dmt-rapidly-reduces-symptoms-of-major-depression
Primary article: https://www.nature.com/articles/s41591-025-04154-z
When the immune system detects a protein from a pathogen,
it’s supposed to dispatch killer T cells to eliminate the invader.
Some cancers can interfere with this process by hijacking the checkpoint proteins that keep our immune system from revving out of control
and using them to turn T cells off.
Starting in the mid-1990s, several research teams found success by treating mice with #checkpoint #inhibitors,
-- then a new class of drugs designed to keep tumor cells from concealing their identity and signaling, effectively, “nothing to see here.”
Thirty years on, checkpoint inhibitors have become a transformative tool in cancer treatment, especially for melanoma.
The research that went into developing checkpoint inhibitors showed conclusively that immune cells detect cancer much in the same way they identify other pathogens:
through differences in protein structure determined by DNA
—a crucial insight.
But as revolutionary as checkpoint inhibitors have been for immunotherapy, they don’t work for everyone
—far from it.
Some 80 percent of patients do not respond to this class of drugs.
Researchers are still trying to understand all the mechanisms that play a role in determining who does respond,
but one key factor is whether the immune system is able to recognize tumor cells on the basis of their mutations.
This is where mRNA vaccines come in.
#Jason #Luke, a melanoma researcher who now serves as chief medical officer of mRNA-medicine start-up #Strand #Therapeutics,
helped to design several ongoing clinical trials of mRNA vaccines for cancer.
He explains that both checkpoint inhibitors and mRNA vaccines build on our deep evolutionary adaptation for fighting pathogens
by identifying the proteins they shed in our bodies.
But checkpoint inhibitors are effective only if the patient’s immune system recognizes the cancer as a threat.
In contrast, mRNA vaccines have the potential to work even in patients whose cancers haven’t spurred much immune response.
The trick, Luke says, is using computational tools to decipher which of a given tumor’s mutations are most likely to be found by the immune system.
RE: https://mastodon.social/@HafizHusnain/115328490796649616
This review connects molecular biology and clinical neuroscience, showing how #miRNAs could transform how we diagnose and treat neurodegenerative diseases.
Click Here to Access Full Article: https://rdcu.be/eJJJ3
#Neuroscience #Neurodegeneration #Biomarkers #miRNA #MolecularBiology #Alzheimers #Parkinsons #ALS #Huntingtons #biosensors #NGS #Diagnostics #Therapeutics #AcademicMastodon #OpenScience #springernature
Since its release last year, the open-source platform BindCraft, developed at @EPFL, has already disrupted the world of #protein design. BindCraft gives biologists the first automated tool for designing custom protein binders for #therapeutics, #diagnostics, and #biotechnology applications.
🔗 Read our news on this study, now published in Nature! https://actu.epfl.ch/news/an-open-source-ai-platform-to-democratize-protein-/
EthanRusso.org is the personal website of #EthanRusso, MD, a #neurologist and medical #researcher.
I’m proud to announce a new course offering with our partners at MM411, “Certificate of Advanced #Cannabis #Pharmacology & #Therapeutics”. This course is for practitioners and professionals who want to provide evidence-based care and support to patients seeking alternatives to conventional pharmaceutical therapies.
Scientific Frontline
TTRPGkids
Psychotherapy Commission ACPE
Das
Chuck Darwin
Giuseppe Michieli
Husnain
EPFL School of Engineering
Karl Theodor