Stephan HackerMay 27

Interesting paper by the groups of Jongmin Park, Juyong Lee and Hankum Park in Nature Communications. They developed muscle-specific PROTACs engaging the E3 ligase KLHL41. Great to see the most potent molecules with covalent KLHL41 ligands.

https://www.nature.com/articles/s41467-026-73252-4
#Chemistry #ChemBio #TPD

Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation - Nature Communications

PROTACs rely mainly on ubiquitous E3 ligases, limiting tissue selectivity. Here, the authors identify a ligand of muscle specific E3 ligase KLHL41 and develop a covalent PROTAC (cKBD-1) that enables potent, muscle-specific protein degradation in vitro and in vivo.

Nature
Stephan HackerMay 27
Interesting paper by the groups of Jongmin Park, Juyong Lee and Hankum Park in @[email protected]. They developed muscle-specific PROTACs engaging the E3 ligase KLHL41. Great to see the most potent molecules with covalent KLHL41 ligands. www.nature.com/articles/s41... #ChemSky #ChemBio #TPD

Discovery of a KLHL41 Ligand f...
Discovery of a KLHL41 Ligand for Muscle Specific Protein Degradation - Nature Communications

PROTACs rely mainly on ubiquitous E3 ligases, limiting tissue selectivity. Here, the authors identify a ligand of muscle specific E3 ligase KLHL41 and develop a covalent PROTAC (cKBD-1) that enables potent, muscle-specific protein degradation in vitro and in vivo.

Nature
Show threadPutin's IBSMay 15

Targets hit:
🔥#BE_200 amphibious aircraft;
🔥#Ka_27 helicopter;
🔥#Tor_M2_SAM system;
🔥#Pantsyr_S1_SAM system;
🔥dry cargo ship with #BK;
🔥#Russian training center and #TPD.

Also, #Magyar confirmed a "courtesy visit" to the #Ryazan_Refinery together with units of deep strike of the #Special_Operations_Forces and the #Main_Intelligence_Directorate.

#ukraine #putinisamasskiller #putinisawarcriminal @kardinal691

Show threadStephan HackerMay 9
Congratulations to @[email protected] and all others involved at @[email protected], Arvinas and Pfizer. #InducedProximity should be at the top of many The Nobel Prize lists now. #TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success #ChemSky #ChemBio
Show threadStephan HackerMay 9

Congratulations to Craig @crews and all others involved at Yale University, Arvinas and Pfizer. #InducedProximity should be at the top of many Nobel Prize lists now. (2/2)

#TPD #TargetedProteinDegradation #NewModalities #Clinics #DrugDiscovery #DrugDevelopment #Success

GDCh Division of BiochemistryMar 17

The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee. "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases".

https://www.nature.com/articles/nchembio.2045
#ChemBio #Biochemistry #Chemistry #ubiquitin #TPD #degradation
CC: @gdch

Follow GOLFMar 15
https://www.fogolf.com/1192989/at-least-two-shot-near-golf-links-kolb/ At least two shot near Golf Links, Kolb #CRIME #Golf #GolfLinksAndKolb #GolfNews #GunViolence #police #Shooting #TPD
Stephan HackerFeb 26
Amazing @[email protected] Lecture by @[email protected]! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3) www.nature.com/articles/s41... #TPD #DrugDiscovery #ChemBio #ChemSky #Degron
LED3hubFeb 26

We are very happy that Christina Woo visited us today for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.

#TPD #ChemBio #Chemistry

Stephan HackerFeb 2

RE: https://mstdn.science/@LED3hub/116002397339883235

Very much looking forward to the @LED3hub Lecture by Christina Woo! I am sure it will be a great one.

If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.

#Chemistry #ChemBio #DrugDiscovery #degrader