One-for-one or one-for-all? Considerations for filovirus vaccine development

Filoviruses continue to re-emerge in Africa, causing localized public health emergencies. Vaccination has slowly been implemented for Ebola virus, but not other filoviruses. This Perspective highlights the importance of taking a holistic approach to protect against filoviruses, discussing possible strategies to achieve cross-protection.

#Remdesivir, mAb114, REGN-EB3, and #ZMapp partially rescue nonhuman #primates infected with a low passage #Kikwit variant of #Ebola virus

:: Pandemic Simulator ::

Ebola-infected monkeys cured with a pill, sparking human treatment hopes

Monkeys infected with Ebola can be cured with a pill, according to a new study out Friday that could pave the way for more practical, affordable treatments in humans.

Bluesky

Remember ebola?

Kyoto, Japan -- Six years before the start of the COVID-19 pandemic, an Ebola outbreak in West Africa had people fearing the possibility of a global outbreak. This was the first time many had ever heard of the virus, but since it was first identified in 1976, there have actually been more than 20 serious Ebola incidents. Thankfully, none of them had the global reach of the coronavirus. Ebola has not been eradicated, however. This deadly virus, which causes severe hemorrhagic fever in humans and has a fatality rate of about 50%, is still at large and could thus still cause a major outbreak, unless further research finds an effective solution. A major challenge lies in the virus' structure and regulatory mechanisms, which have remained largely unclear. In particular, scientists have long struggled to fully understand its nucleocapsid, the protein shell that plays an important role in genome replication and transcription.