michaelMar 28, 2025

26-Mar-2025
Remember #ebola?
Zooming in on the #structure of the still lethal #virus

https://www.eurekalert.org/news-releases/1078261 #science #structuralBiology #protein #capsid

Remember ebola?

Kyoto, Japan -- Six years before the start of the COVID-19 pandemic, an Ebola outbreak in West Africa had people fearing the possibility of a global outbreak. This was the first time many had ever heard of the virus, but since it was first identified in 1976, there have actually been more than 20 serious Ebola incidents. Thankfully, none of them had the global reach of the coronavirus. Ebola has not been eradicated, however. This deadly virus, which causes severe hemorrhagic fever in humans and has a fatality rate of about 50%, is still at large and could thus still cause a major outbreak, unless further research finds an effective solution. A major challenge lies in the virus' structure and regulatory mechanisms, which have remained largely unclear. In particular, scientists have long struggled to fully understand its nucleocapsid, the protein shell that plays an important role in genome replication and transcription.

EurekAlert!
Amelia Cervera 🧬Jan 20, 2025
Passage of the HIV capsid cracks the nuclear pore.
#HIV #capsid #NuclearPoreComplex #FGNups
https://www.cell.com/cell/fulltext/S0092-8674(24)01421-1
Stefan Geier, HaidholzenJul 24, 2024

My contribution to 25. Welt-#AIDS-Konferenz #AIDS2024 of the IAS - International AIDS Society in #München:

HIV capsid: 12 pentamers and quantum biology allow new ways of drug development!

Please, see that the number 12 in the HIV capsid molecule consisting of exactly 12 pentamers ... fits our concept on the relevance of M-theory and F-theory in the explanation of virology, biochemistry, and biology at the nanoscale. ...
SG

#AIDS #HIV #virus #p24 #capsid #virology #RNA

https://humanistischebetrachtungen1.blogspot.com/2024/07/aids2024-hiv-capsid-12-pentamers-and.html

AIDS2024 The HIV capsid: 12 pentamers and quantum biology allow new ways of drug development

 #AIDS2024 The   HIV capsid: 12 pentamers  and quantum biology allow new ways of drug development by Stefan A. Geier Please, see that the ...

katch wreckJun 28, 2024

"In addition, while the capsid is associated with budding initiation, it is not required for curvature formation. By determining the NEC structure in several #conformations, we show that curvature arises from an asymmetric assembly of disordered and hexagonally ordered lattice domains independent of pUL25 or other #viral #capsid vertex components. Our results advance our understanding of the mechanism of nuclear egress in the context of a living cell."

https://www.nature.com/articles/s41564-024-01716-8

Molecular plasticity of herpesvirus nuclear egress analysed in situ - Nature Microbiology

Visualizing the stages of herpesvirus nuclear egress in situ using cryoET and subvolume averaging shows how nascent virions pass through the nuclear membrane.

Nature
CellBioNewsNov 9, 2023

#Temperature increase triggers #viral #infection: Research maps what happens on an atomic level.

#phage #DNA #capsid

https://phys.org/news/2023-11-temperature-triggers-viral-infection-atomic.html

Temperature increase triggers viral infection: Research maps what happens on an atomic level

Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the U.S., have mapped on an atomic level what happens in a virus particle when the temperature is raised.

Phys.org
Scientific FrontlineNov 8, 2023
In most cases, the virus's #genetic material, #DNA is enclosed within a protective protein shell called a #capsid . A research group at Lund University is working to understand the process by which the #virus ejects its genetic material from the capsid and into cells and what causes the virus's DNA to be released.
#Biology #Virology #sflorg
https://www.sflorg.com/2023/11/bio11082302.html
Temperature increase triggers viral infection

Viruses lack their own metabolism and the ability to replicate independently

CellBioNewsOct 12, 2023

#HPV discovery yields breakthrough in understanding #protein activity.

#phylogenomics #primary_structure #capsid #L2

https://phys.org/news/2023-10-hpv-discovery-yields-breakthrough-protein.html

HPV discovery yields breakthrough in understanding protein activity

A new study led by Yale scientists shows that the activity of a portion of a human papillomavirus (HPV) protein does not depend on its amino acid sequence or composition. This discovery challenges the widely held belief that protein function is solely determined by a specific amino acid sequence.

Phys.org
Mr Juan VeraAug 6, 2023

Well, I asked #Bard (Google's AI) about whether #mutations could be caused in the #proteins that make up the #capsid of the #virus that is, as #prionism.

The answer was as expected, YES, as this could make the #viruses more #infectious and #lethal.

My #brain is an INEXPLICABLY COOL thing.

#DNA #RNA #Virus #Genome #Mutation #Biophysics #Biology #Molecular #Transcription #Vaccine

Vivek MutalikJan 21, 2023

Direct activation of a #bacterial innate immune system by a viral #capsid protein | Nature

https://www.nature.com/articles/s41586-022-05444-z

Direct activation of a bacterial innate immune system by a viral capsid protein - Nature

Genetic, biochemical and structural studies provide insights into the function of Escherichia coli CapRelSJ46 as a fused anti-phage toxin–antitoxin system that binds SECΦ27 Gp57 capsid protein.

Nature