Mastodawn

🦴 Could a naturally occurring “biological lubricant” redefine how we treat joint health and gout?

🔗 Lubricin’s Mucin Domain Has Strong Polyproline Type II Helical Character. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0021

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #ProteinScience #Biophysics #ComputationalBiology #Osteoarthritis #Glycoproteins #MolecularBiology

Guillaume Gaullier 2d ago

Here is a strong candidate for the coolest-looking #cryoEM structure of 2026! 🤩

Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity

https://doi.org/10.1038/s41586-026-10255-7

#StructuralBiology

CSBJ 4d ago

🦠 Could algorithms help us outpace evolving superbugs?

🔗 Antibacterial Drug Discovery: Deep Learning Successes and Challenges through the Structural Biology Lens. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0008

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntibioticResistance #DrugDiscovery #ComputationalBiology #StructuralBiology #MachineLearning #Bioinformatics

Scientific Frontline 5d ago

The nascent polypeptide-associated complex (NAC) is a critical molecular control center in eukaryotes that binds to emerging amino acid chains at the ribosome. It initiates the essential first steps of folding these chains into their correct three-dimensional functional structures.
#MolecularBiology #CellBiology #Biochemistry #StructuralBiology #sflorg
https://www.sflorg.com/2026/03/mbio03232601.html

New Findings on the First Steps in Protein Synthesis

International research team under heidelberg supervision examines role of NAC complex in essential process of protein folding

Nithin C 6d ago

Our new paper published in the Computational and Structural Biotechnology Journal explains how ligands binding the exact same IL1R1 site produce opposite outcomes.

We used MD simulations and CABS-flex to show how IL1 receptor antagonists block signaling despite binding the exact same site as agonists. Instead of a static blockade, antagonists actively disrupt distal D3 domain dynamics.

Read here: https://doi.org/10.34133/csbj.0017

#MolecularDynamics #Biophysics #StructuralBiology #Allostery

CSBJ Mar 22

🧱 What if activation and inhibition are not about binding but about motion?

🔗 Antagonist Binding Actively Disrupts Interleukin-1 Receptor Dynamics to Block Co-receptor Recruitment. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0017

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#DrugDiscovery #Immunology #ProteinDynamics #Inflammation #Biophysics #StructuralBiology #ComputationalBiology #Cytokines

Scientific Frontline Mar 21

Researchers engineered a new class of T cells that utilize a mechanical "catch bond" to strengthen their physical interaction with prostate cancer cells, enabling a highly targeted, potent, and sustained immune response.
#Immunology #Oncology #MolecularBiology #StructuralBiology #sflorg
https://www.sflorg.com/2026/03/imgy03212601.html

Scientists turbocharge immune cells to attack prostate cancer

A more effective T cell therapies for prostate cancer and other solid tumors

Scientific Frontline Mar 21

CryoPRISM (purification-free ribosome imaging from subcellular mixtures) is an advanced structural biology imaging technique that enables researchers to observe biomolecular complexes, such as ribosomes, within their near-natural cellular environments.
#CryoPRISM #StructuralBiology #MolecularBiology #CellBiology #Microbiology #sflorg
https://www.sflorg.com/2026/03/bio03212601.html

CryoPRISM: A new tool for observing cellular machinery in a more natural environment

The method allows researchers to observe biomolecular complexes in a quick, accurate, and budget-friendly way, providing new insights into bacterial

Scientific Frontline Mar 19

Researchers have developed and observed a light-switchable blood pressure medication that alters its molecular shape and potency when exposed to specific wavelengths of light. This advancement allows the drug's therapeutic effects to be modulated with precise timing and localization within the body.
#Photopharmacology #StructuralBiology #Biochemistry #Pharmacology #sflorg
https://www.sflorg.com/2026/03/phar03192601.html

Blood pressure-lowering drug with a light switch

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology

michael Mar 19

17-Mar-2026
Millions of #protein complexes added to #AlphaFold Database shed light on how proteins interact

https://www.eurekalert.org/news-releases/1119736

#science #structuralBiology

Millions of protein complexes added to AlphaFold Database shed light on how proteins interact

Four-way collaboration brings together world-leading AI and biological expertise to make AI-predicted protein complex structures openly available to the global scientific community

EurekAlert!