Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye report Harvard ophthalmologists.
#cornea #stemcells #limbus #calec https://www.instagram.com/reel/DH9UqL2spnA/
Howard G. Smith MD, AM on Instagram: "Cells From One Eye Can Heal The Other
Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye. Ophthalmologists at Harvard’s Mass. Eye and Ear Infirmary developed what they term the CALEC procedure, an acronym for Cultivated Autologous Limbal Epithelial Cells.
The limbal region of the cornea contains stem cells that constantly renew the corneal surface. These cells are harvested and grown out into a tissue graft in a laboratory at Boston’s Dana-Farber Cancer Institute. The graft is then implanted in the diseased eye.
The researchers report their preliminary trial of 14 patients in the journal Nature Communications. The procedure boasts a 93% success rate for significant corneal repair with 79% of the subjects enjoying complete restoration of their injured corneas by 1 year postoperatively.
After additional trials are complete, this procedure will be ready to restore sight in eyes once considered hopelessly blinded…. Someday soon.
https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/calec-stem-cell-therapy-clinical-trial-repairs-corneal-damage
#cornea #stemcells #limbus #calec"
0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Cells From One Eye Can Heal The Other
Cells taken from the edge of a healthy cornea can become a magic bullet to repair a previously considered irreparable cornea in the opposite eye. Ophthalmologists at Harvard’s Mass. Eye and Ear Infirmary developed what they term the CALEC procedure, an acronym for Cultivated Autologous Limbal Epithelial Cells.
The limbal region of the cornea contains stem cells that constantly renew the corneal surface. These cells are harvested and grown out into a tissue graft in a laboratory at Boston’s Dana-Farber Cancer Institute. The graft is then implanted in the diseased eye.
The researchers report their preliminary trial of 14 patients in the journal Nature Communications. The procedure boasts a 93% success rate for significant corneal repair with 79% of the subjects enjoying complete restoration of their injured corneas by 1 year postoperatively.
After additional trials are complete, this procedure will be ready to restore sight in eyes once considered hopelessly blinded…. Someday soon.
https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/calec-stem-cell-therapy-clinical-trial-repairs-corneal-damage
#cornea #stemcells #limbus #calec".
La terapia CALEC è una svolta epocale per chi ha perso la vista a causa di danni corneali. Prelevando cellule staminali dall'occhio sano per rigenerare quello danneggiato, ha raggiunto un impressionante tasso di successo del 92% nei pazienti trattati. Dopo due decenni di ricerca, una procedura che ridà letteralmente la luce a chi viveva nel buio.
#CALEC #Staminali #Cornea #Medicina #Vista
https://www.futuroprossimo.it/2025/03/e-luce-fu-calec-rida-la-vista-ai-pazienti-con-danni-alla-cornea/
E luce fu: CALEC ridà la vista ai pazienti con danni alla cornea
La terapia CALEC con cellule staminali ha ripristinato la vista in 14 pazienti con danni corneali considerati incurabili.
SciTech Chronicles. . . . . . . . .Mar 5th, 2025
I am only responsible for what I say, not what you understand. Vol II No 58 417 links Curated A new therapy repairs corneal damage to a pati...
Trapianto di cornea per Enzo Avitabile
Questa mattina Enzo Avitabile si è sottoposto a un intervento di trapianto di cornea presso l’Irccs Policlinico di Sant’Orsola a
I wish I could thank the anonymous person who checked the organ donor box on their driver's license. I will carry a portion of their eye with me forever after receiving a partial cornea transplant last week to correct a progressive degenerative disorder.
#OrganDonor #transplant #cornea #FuchsDystrophy #DSEK #eye
Unravelling the mysteries of corneal cell migration with active matter physics 👁️ ⚛
Prasanna Padmanaban highlights recent work from Kaja Kostanjevec & team in his latest #preLight.
Take a look! ⬇️ 👀
preLight: https://prelights.biologists.com/highlights/spiral-eyes-a-soft-active-matter-model-of-in-vivo-corneal-epithelial-cell-migration/
#biology #preprint #physics #eye #cornea #cells #migration
Spiral-eyes: A soft active matter model of in vivo corneal epithelial cell migration - preLights
Unraveling the mysteries of corneal cell migration with active matter physics.
Despite its lack of blood vessels, the cornea can heal relatively quickly from minor injuries because of its rich supply of nerve endings and access to nutrients from surrounding fluids.
#science #sciencefacts #humaneye #cornea
Excited to have a new article out! This is a novel corneal dystrophy with a story going back at least 15 years
Autosomal dominant stromal corneal dystrophy associated with a SPARCL1 missense variant by Braddock et al. Well done, team!
https://www.nature.com/articles/s41431-024-01687-8
#ophthalmology #cornea #genetics #OpenAccess #MedMastodon #EyePath
Autosomal dominant stromal corneal dystrophy associated with a SPARCL1 missense variant - European Journal of Human Genetics
Corneal dystrophies are phenotypically and genetically heterogeneous, often resulting in visual impairment caused by corneal opacification. We investigated the genetic cause of an autosomal dominant corneal stromal dystrophy in a pedigree with eight affected individuals in three generations. Affected individuals had diffuse central stromal opacity, with reduced visual acuity in older family members. Histopathology of affected cornea tissue removed during surgery revealed mild stromal textural alterations with alcianophilic deposits. Whole genome sequence data were generated for four affected individuals. No rare variants (MAF < 0.001) were identified in established corneal dystrophy genes. However, a novel heterozygous missense variant in exon 4 of SPARCL1, NM_004684: c.334G > A; p.(Glu112Lys), which is predicted to be damaging, segregated with disease. SPARC-like protein 1 (SPARCL1) is a secreted matricellular protein involved in cell migration, cell adhesion, tissue repair, and remodelling. Interestingly, SPARCL1 has been shown to regulate decorin. Heterozygous variants in DCN, encoding decorin, cause autosomal dominant congenital stromal corneal dystrophy, suggesting a common pathogenic pathway. Therefore, we performed immunohistochemistry to compare SPARCL1 and decorin localisation in corneal tissue from an affected family member and an unaffected control. Strikingly, the level of decorin was significantly decreased in the corneal stroma of the affected tissue, and SPARCL1 appeared to be retained in the epithelium. In summary, we describe a novel autosomal dominant corneal stromal dystrophy associated with a missense variant in SPARCL1, extending the phenotypic and genetic heterogeneity of inherited corneal disease.
Policoria
Aunque son casos raros Una persona puede tener dos o más pupilas en un ojo; esta condición se llama "policoria".
#policoria #cornea #ojos #pupilas #JMS
Howard Smith MD, AM
Futuro Prossimo 
John Vaccaro (johniac)
LaRampa.it
Anson
The-14
preLights
ScienceActually
MH Thaung
JMS